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Seeded strain-like transmission of β-amyloid morphotypes in APP transgenic mice.

Overview of attention for article published in EMBO Reports, September 2013
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (89th percentile)
  • Good Attention Score compared to outputs of the same age and source (75th percentile)

Mentioned by

news
1 news outlet
blogs
1 blog

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mendeley
81 Mendeley
Title
Seeded strain-like transmission of β-amyloid morphotypes in APP transgenic mice.
Published in
EMBO Reports, September 2013
DOI 10.1038/embor.2013.137
Pubmed ID
Authors

Heilbronner G, Eisele YS, Langer F, Kaeser SA, Novotny R, Nagarathinam A, Aslund A, Hammarström P, Nilsson KP, Jucker M

Abstract

The polymorphic β-amyloid lesions present in individuals with Alzheimer's disease are collectively known as cerebral β-amyloidosis. Amyloid precursor protein (APP) transgenic mouse models similarly develop β-amyloid depositions that differ in morphology, binding of amyloid conformation-sensitive dyes, and Aβ40/Aβ42 peptide ratio. To determine the nature of such β-amyloid morphotypes, β-amyloid-containing brain extracts from either aged APP23 brains or aged APPPS1 brains were intracerebrally injected into the hippocampus of young APP23 or APPPS1 transgenic mice. APPPS1 brain extract injected into young APP23 mice induced β-amyloid deposition with the morphological, conformational, and Aβ40/Aβ42 ratio characteristics of β-amyloid deposits in aged APPPS1 mice, whereas APP23 brain extract injected into young APP23 mice induced β-amyloid deposits with the characteristics of β-amyloid deposits in aged APP23 mice. Injecting the two extracts into the APPPS1 host revealed a similar difference between the induced β-amyloid deposits, although less prominent, and the induced deposits were similar to the β-amyloid deposits found in aged APPPS1 hosts. These results indicate that the molecular composition and conformation of aggregated Aβ in APP transgenic mice can be maintained by seeded conversion.

Mendeley readers

The data shown below were compiled from readership statistics for 81 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 2 2%
United States 2 2%
France 1 1%
United Kingdom 1 1%
Ireland 1 1%
Austria 1 1%
Unknown 73 90%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 24 30%
Researcher 16 20%
Student > Master 11 14%
Other 7 9%
Student > Bachelor 6 7%
Other 17 21%
Readers by discipline Count As %
Agricultural and Biological Sciences 40 49%
Neuroscience 12 15%
Biochemistry, Genetics and Molecular Biology 9 11%
Medicine and Dentistry 9 11%
Unspecified 6 7%
Other 5 6%

Attention Score in Context

This research output has an Altmetric Attention Score of 12. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 January 2017.
All research outputs
#789,830
of 8,862,686 outputs
Outputs from EMBO Reports
#276
of 1,838 outputs
Outputs of similar age
#18,279
of 177,434 outputs
Outputs of similar age from EMBO Reports
#8
of 33 outputs
Altmetric has tracked 8,862,686 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 90th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,838 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.0. This one has done well, scoring higher than 84% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 177,434 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 89% of its contemporaries.
We're also able to compare this research output to 33 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 75% of its contemporaries.