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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Phase I Hydroxylated Metabolites of the K2 Synthetic Cannabinoid JWH-018 Retain In Vitro and In Vivo Cannabinoid 1 Receptor Affinity and Activity
|
|---|---|
| Published in |
PLOS ONE, July 2011
|
| DOI | 10.1371/journal.pone.0021917 |
| Pubmed ID | |
| Authors |
Lisa K. Brents, Emily E. Reichard, Sarah M. Zimmerman, Jeffery H. Moran, William E. Fantegrossi, Paul L. Prather |
| Abstract |
K2 products are synthetic cannabinoid-laced, marijuana-like drugs of abuse, use of which is often associated with clinical symptoms atypical of marijuana use, including hypertension, agitation, hallucinations, psychosis, seizures and panic attacks. JWH-018, a prevalent K2 synthetic cannabinoid, is structurally distinct from Δ(9)-THC, the main psychoactive ingredient in marijuana. Since even subtle structural differences can lead to differential metabolism, formation of novel, biologically active metabolites may be responsible for the distinct effects associated with K2 use. The present study proposes that K2's high adverse effect occurrence is due, at least in part, to distinct JWH-018 metabolite activity at the cannabinoid 1 receptor (CB1R). |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 165 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 5 | 3% |
| Poland | 2 | 1% |
| Netherlands | 1 | <1% |
| United Kingdom | 1 | <1% |
| Switzerland | 1 | <1% |
| Unknown | 155 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 30 | 18% |
| Student > Ph. D. Student | 26 | 16% |
| Researcher | 25 | 15% |
| Other | 18 | 11% |
| Student > Master | 15 | 9% |
| Other | 27 | 16% |
| Unknown | 24 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Chemistry | 28 | 17% |
| Medicine and Dentistry | 28 | 17% |
| Agricultural and Biological Sciences | 26 | 16% |
| Pharmacology, Toxicology and Pharmaceutical Science | 14 | 8% |
| Psychology | 11 | 7% |
| Other | 26 | 16% |
| Unknown | 32 | 19% |
Attention Score in Context
This research output has an Altmetric Attention Score of 17. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 November 2018.
All research outputs
#2,037,587
of 24,739,153 outputs
Outputs from PLOS ONE
#25,222
of 214,155 outputs
Outputs of similar age
#9,031
of 120,663 outputs
Outputs of similar age from PLOS ONE
#288
of 2,147 outputs
Altmetric has tracked 24,739,153 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 91st percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 214,155 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.6. This one has done well, scoring higher than 88% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 120,663 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 92% of its contemporaries.
We're also able to compare this research output to 2,147 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 86% of its contemporaries.