Title |
Mouse CCDC79 (TERB1) is a meiosis-specific telomere associated protein
|
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Published in |
BMC Molecular and Cell Biology, May 2014
|
DOI | 10.1186/1471-2121-15-17 |
Pubmed ID | |
Authors |
Katrin Daniel, Daniel Tränkner, Lukasz Wojtasz, Hiroki Shibuya, Yoshinori Watanabe, Manfred Alsheimer, Attila Tóth |
Abstract |
Telomeres have crucial meiosis-specific roles in the orderly reduction of chromosome numbers and in ensuring the integrity of the genome during meiosis. One such role is the attachment of telomeres to trans-nuclear envelope protein complexes that connect telomeres to motor proteins in the cytoplasm. These trans-nuclear envelope connections between telomeres and cytoplasmic motor proteins permit the active movement of telomeres and chromosomes during the first meiotic prophase. Movements of chromosomes/telomeres facilitate the meiotic recombination process, and allow high fidelity pairing of homologous chromosomes. Pairing of homologous chromosomes is a prerequisite for their correct segregation during the first meiotic division. Although inner-nuclear envelope proteins, such as SUN1 and potentially SUN2, are known to bind and recruit meiotic telomeres, these proteins are not meiosis-specific, therefore cannot solely account for telomere-nuclear envelope attachment and/or for other meiosis-specific characteristics of telomeres in mammals. |
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