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Autoinducer-2 Plays a Crucial Role in Gut Colonization and Probiotic Functionality of Bifidobacterium breve UCC2003

Overview of attention for article published in PLOS ONE, May 2014
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (77th percentile)
  • Good Attention Score compared to outputs of the same age and source (69th percentile)

Mentioned by

twitter
4 tweeters
patent
30 patents

Citations

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49 Dimensions

Readers on

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76 Mendeley
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Title
Autoinducer-2 Plays a Crucial Role in Gut Colonization and Probiotic Functionality of Bifidobacterium breve UCC2003
Published in
PLOS ONE, May 2014
DOI 10.1371/journal.pone.0098111
Pubmed ID
Authors

Steven E. A. Christiaen, Mary O'Connell Motherway, Francesca Bottacini, Noreen Lanigan, Pat G. Casey, Geert Huys, Hans J. Nelis, Douwe van Sinderen, Tom Coenye

Abstract

In the present study we show that luxS of Bifidobacterium breve UCC2003 is involved in the production of the interspecies signaling molecule autoinducer-2 (AI-2), and that this gene is essential for gastrointestinal colonization of a murine host, while it is also involved in providing protection against Salmonella infection in Caenorhabditis elegans. We demonstrate that a B. breve luxS-insertion mutant is significantly more susceptible to iron chelators than the WT strain and that this sensitivity can be partially reverted in the presence of the AI-2 precursor DPD. Furthermore, we show that several genes of an iron starvation-induced gene cluster, which are downregulated in the luxS-insertion mutant and which encodes a presumed iron-uptake system, are transcriptionally upregulated under in vivo conditions. Mutation of two genes of this cluster in B. breve UCC2003 renders the derived mutant strains sensitive to iron chelators while deficient in their ability to confer gut pathogen protection to Salmonella-infected nematodes. Since a functional luxS gene is present in all tested members of the genus Bifidobacterium, we conclude that bifidobacteria operate a LuxS-mediated system for gut colonization and pathogen protection that is correlated with iron acquisition.

Twitter Demographics

The data shown below were collected from the profiles of 4 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 76 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Czechia 1 1%
Argentina 1 1%
Unknown 74 97%

Demographic breakdown

Readers by professional status Count As %
Researcher 19 25%
Student > Ph. D. Student 15 20%
Student > Master 9 12%
Student > Bachelor 6 8%
Other 5 7%
Other 10 13%
Unknown 12 16%
Readers by discipline Count As %
Agricultural and Biological Sciences 26 34%
Immunology and Microbiology 15 20%
Biochemistry, Genetics and Molecular Biology 10 13%
Medicine and Dentistry 4 5%
Chemistry 2 3%
Other 4 5%
Unknown 15 20%

Attention Score in Context

This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 March 2022.
All research outputs
#5,090,947
of 21,322,016 outputs
Outputs from PLOS ONE
#57,724
of 182,597 outputs
Outputs of similar age
#46,365
of 205,323 outputs
Outputs of similar age from PLOS ONE
#948
of 3,119 outputs
Altmetric has tracked 21,322,016 research outputs across all sources so far. Compared to these this one has done well and is in the 76th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 182,597 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 14.6. This one has gotten more attention than average, scoring higher than 68% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 205,323 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 77% of its contemporaries.
We're also able to compare this research output to 3,119 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 69% of its contemporaries.