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Autophagy Is Required for Glucose Homeostasis and Lung Tumor Maintenance

Overview of attention for article published in Cancer Discovery, May 2014
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (97th percentile)
  • High Attention Score compared to outputs of the same age and source (98th percentile)

Citations

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369 Dimensions

Readers on

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271 Mendeley
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Title
Autophagy Is Required for Glucose Homeostasis and Lung Tumor Maintenance
Published in
Cancer Discovery, May 2014
DOI 10.1158/2159-8290.cd-14-0363
Pubmed ID
Authors

Gizem Karsli-Uzunbas, Jessie Yanxiang Guo, Sandy Price, Xin Teng, Saurabh V Laddha, Sinan Khor, Nada Y. Kalaany, Tyler Jacks, Chang S. Chan, Joshua D. Rabinowitz, Eileen White

Abstract

Macroautophagy (autophagy hereafter) recycles intracellular components to sustain mitochondrial metabolism that promotes the growth, stress tolerance and malignancy of lung cancers, suggesting that autophagy inhibition may have antitumor activity. To assess the functional significance of autophagy in both normal and tumor tissue, we conditionally deleted the essential autophagy gene, autophagy-related-7, Atg7, throughout adult mice. Here we report that systemic ATG7 ablation caused susceptibility to infection and neurodegeneration that limited survival to 2-3 months. Moreover, upon fasting, autophagy-deficient mice suffered fatal hypoglycemia. Prior autophagy ablation did not alter the efficiency of non-small-cell lung cancer (NSCLC) initiation by activation of oncogenic KrasG12D and deletion of the Trp53 tumor suppressor. Acute autophagy ablation in mice with pre-existing NSCLC, however, blocked tumor growth, promoted tumor cell death, and generated more benign disease (oncocytomas). This anti-tumor activity occurred prior to destruction of normal tissues, suggesting that, acute autophagy inhibition may be therapeutically beneficial in cancer.

Twitter Demographics

The data shown below were collected from the profiles of 6 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 271 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Japan 1 <1%
Spain 1 <1%
Belgium 1 <1%
Unknown 268 99%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 56 21%
Researcher 54 20%
Student > Bachelor 30 11%
Student > Master 19 7%
Student > Doctoral Student 11 4%
Other 41 15%
Unknown 60 22%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 78 29%
Agricultural and Biological Sciences 54 20%
Medicine and Dentistry 29 11%
Pharmacology, Toxicology and Pharmaceutical Science 8 3%
Immunology and Microbiology 7 3%
Other 24 9%
Unknown 71 26%

Attention Score in Context

This research output has an Altmetric Attention Score of 67. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 January 2022.
All research outputs
#467,337
of 20,815,952 outputs
Outputs from Cancer Discovery
#232
of 3,324 outputs
Outputs of similar age
#5,021
of 205,074 outputs
Outputs of similar age from Cancer Discovery
#2
of 60 outputs
Altmetric has tracked 20,815,952 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,324 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 18.1. This one has done particularly well, scoring higher than 93% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 205,074 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 60 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 98% of its contemporaries.