Title |
Obesity is associated with increased seminal insulin and leptin alongside reduced fertility parameters in a controlled male cohort
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Published in |
Reproductive Biology and Endocrinology, May 2014
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DOI | 10.1186/1477-7827-12-34 |
Pubmed ID | |
Authors |
Kristian Leisegang, Patrick JD Bouic, Roelof Menkveld, Ralf R Henkel |
Abstract |
Obesity appears to be associated with male reproductive dysfunction and infertility, although this has been inconsistent and inconclusive. Insulin and leptin are known mediators and modulators of the hypothalamus-pituitary-testes axis, contributing to the regulation of male reproductive potential and overall wellbeing. These hormones are also present in semen influencing sperm functions. Although abdominal obesity is closely associated with insulin resistance (hyperinsulinaemia), hyperleptinaemia and glucose dysfunction, changes in seminal plasma concentrations of insulin, leptin and glucose in obese males has not previously been investigated. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 88 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Bachelor | 13 | 15% |
Student > Master | 12 | 14% |
Researcher | 10 | 11% |
Student > Doctoral Student | 7 | 8% |
Student > Ph. D. Student | 5 | 6% |
Other | 9 | 10% |
Unknown | 32 | 36% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 24 | 27% |
Biochemistry, Genetics and Molecular Biology | 12 | 14% |
Agricultural and Biological Sciences | 9 | 10% |
Nursing and Health Professions | 2 | 2% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 1% |
Other | 7 | 8% |
Unknown | 33 | 38% |