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Arginine and Citrulline for the Treatment of MELAS Syndrome

Overview of attention for article published in Journal of Inborn Errors of Metabolism and Screening, March 2017
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (63rd percentile)

Mentioned by

twitter
5 tweeters

Citations

dimensions_citation
35 Dimensions

Readers on

mendeley
50 Mendeley
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Title
Arginine and Citrulline for the Treatment of MELAS Syndrome
Published in
Journal of Inborn Errors of Metabolism and Screening, March 2017
DOI 10.1177/2326409817697399
Pubmed ID
Authors

Ayman W. El-Hattab, Mohammed Almannai, Fernando Scaglia

Abstract

MELAS (mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes) syndrome is a maternally inherited mitochondrial disease with a broad spectrum of manifestations. In addition to impaired energy production, nitric oxide (NO) deficiency occurs in MELAS syndrome and leads to impaired blood perfusion in microvasculature that can contribute to several complications including stroke-like episodes, myopathy, and lactic acidosis. The supplementation of NO precursors, L-arginine and L-citrulline, increases NO production and hence can potentially have therapeutic utility in MELAS syndrome. L-citrulline raises NO production to a greater extent than L-arginine; therefore, L-citrulline may have a better therapeutic effect. The clinical effect of L-citrulline has not yet been studied and clinical studies on L-arginine, which are limited, only evaluated the stroke-like episodes aspect of the disease. Controlled studies are still needed to assess the clinical effects of L-arginine and L-citrulline on different aspects of MELAS syndrome.

Twitter Demographics

The data shown below were collected from the profiles of 5 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 50 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 50 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 10 20%
Researcher 7 14%
Other 5 10%
Student > Master 4 8%
Student > Ph. D. Student 4 8%
Other 8 16%
Unknown 12 24%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 8 16%
Neuroscience 8 16%
Medicine and Dentistry 8 16%
Pharmacology, Toxicology and Pharmaceutical Science 4 8%
Agricultural and Biological Sciences 2 4%
Other 7 14%
Unknown 13 26%

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 March 2022.
All research outputs
#6,929,078
of 22,002,998 outputs
Outputs from Journal of Inborn Errors of Metabolism and Screening
#8
of 49 outputs
Outputs of similar age
#105,037
of 291,827 outputs
Outputs of similar age from Journal of Inborn Errors of Metabolism and Screening
#1
of 1 outputs
Altmetric has tracked 22,002,998 research outputs across all sources so far. This one has received more attention than most of these and is in the 67th percentile.
So far Altmetric has tracked 49 research outputs from this source. They receive a mean Attention Score of 1.6. This one scored the same or higher as 41 of them.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 291,827 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 63% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them