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Alternative Spliced CD1D Transcripts in Human Bronchial Epithelial Cells

Overview of attention for article published in PLOS ONE, August 2011
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Title
Alternative Spliced CD1D Transcripts in Human Bronchial Epithelial Cells
Published in
PLOS ONE, August 2011
DOI 10.1371/journal.pone.0022726
Pubmed ID
Authors

Kambez Hajipouran Benam, Wai Ling Kok, Andrew J. McMichael, Ling-Pei Ho

Abstract

CD1d is a MHC I like molecule which presents glycolipid to natural killer T (NKT) cells, a group of cells with diverse but critical immune regulatory functions in the immune system. These cells are required for optimal defence against bacterial, viral, protozoan, and fungal infections, and control of immune-pathology and autoimmune diseases. CD1d is expressed on antigen presenting cells but also found on some non-haematopoietic cells. However, it has not been observed on bronchial epithelium, a site of active host defence in the lungs. Here, we identify for the first time, CD1D mRNA variants and CD1d protein expression on human bronchial epithelial cells, describe six alternatively spliced transcripts of this gene in these cells; and show that these variants are specific to epithelial cells. These findings provide the basis for investigations into a role for CD1d in lung mucosal immunity.

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X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 25 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Brazil 2 8%
France 1 4%
Unknown 22 88%

Demographic breakdown

Readers by professional status Count As %
Researcher 8 32%
Student > Ph. D. Student 7 28%
Student > Master 3 12%
Student > Postgraduate 2 8%
Other 1 4%
Other 3 12%
Unknown 1 4%
Readers by discipline Count As %
Agricultural and Biological Sciences 11 44%
Medicine and Dentistry 7 28%
Immunology and Microbiology 3 12%
Biochemistry, Genetics and Molecular Biology 2 8%
Business, Management and Accounting 1 4%
Other 0 0%
Unknown 1 4%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 August 2011.
All research outputs
#18,293,967
of 22,649,029 outputs
Outputs from PLOS ONE
#153,637
of 193,361 outputs
Outputs of similar age
#99,829
of 120,757 outputs
Outputs of similar age from PLOS ONE
#1,837
of 2,369 outputs
Altmetric has tracked 22,649,029 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 193,361 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.0. This one is in the 10th percentile – i.e., 10% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 120,757 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 8th percentile – i.e., 8% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 2,369 others from the same source and published within six weeks on either side of this one. This one is in the 7th percentile – i.e., 7% of its contemporaries scored the same or lower than it.