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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Lhx6-positive GABA-releasing neurons of the zona incerta promote sleep
|
|---|---|
| Published in |
Nature, August 2017
|
| DOI | 10.1038/nature23663 |
| Pubmed ID | |
| Authors |
Kai Liu, Juhyun Kim, Dong Won Kim, Yi Stephanie Zhang, Hechen Bao, Myrto Denaxa, Szu-Aun Lim, Eileen Kim, Chang Liu, Ian R. Wickersham, Vassilis Pachnis, Samer Hattar, Juan Song, Solange P. Brown, Seth Blackshaw |
| Abstract |
Multiple populations of wake-promoting neurons have been characterized in mammals, but few sleep-promoting neurons have been identified. Wake-promoting cell types include hypocretin and GABA (γ-aminobutyric-acid)-releasing neurons of the lateral hypothalamus, which promote the transition to wakefulness from non-rapid eye movement (NREM) and rapid eye movement (REM) sleep. Here we show that a subset of GABAergic neurons in the mouse ventral zona incerta, which express the LIM homeodomain factor Lhx6 and are activated by sleep pressure, both directly inhibit wake-active hypocretin and GABAergic cells in the lateral hypothalamus and receive inputs from multiple sleep-wake-regulating neurons. Conditional deletion of Lhx6 from the developing diencephalon leads to decreases in both NREM and REM sleep. Furthermore, selective activation and inhibition of Lhx6-positive neurons in the ventral zona incerta bidirectionally regulate sleep time in adult mice, in part through hypocretin-dependent mechanisms. These studies identify a GABAergic subpopulation of neurons in the ventral zona incerta that promote sleep. |
X Demographics
The data shown below were collected from the profiles of 124 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Saudi Arabia | 24 | 19% |
| United States | 21 | 17% |
| Japan | 7 | 6% |
| Italy | 4 | 3% |
| United Kingdom | 3 | 2% |
| China | 2 | 2% |
| Canada | 1 | <1% |
| Argentina | 1 | <1% |
| Korea, Republic of | 1 | <1% |
| Other | 4 | 3% |
| Unknown | 56 | 45% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 107 | 86% |
| Scientists | 9 | 7% |
| Practitioners (doctors, other healthcare professionals) | 4 | 3% |
| Science communicators (journalists, bloggers, editors) | 4 | 3% |
Mendeley readers
The data shown below were compiled from readership statistics for 257 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 257 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 59 | 23% |
| Student > Ph. D. Student | 54 | 21% |
| Student > Master | 20 | 8% |
| Student > Doctoral Student | 14 | 5% |
| Student > Bachelor | 14 | 5% |
| Other | 44 | 17% |
| Unknown | 52 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 104 | 40% |
| Agricultural and Biological Sciences | 50 | 19% |
| Medicine and Dentistry | 13 | 5% |
| Biochemistry, Genetics and Molecular Biology | 10 | 4% |
| Engineering | 7 | 3% |
| Other | 14 | 5% |
| Unknown | 59 | 23% |
Attention Score in Context
This research output has an Altmetric Attention Score of 175. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 January 2023.
All research outputs
#235,815
of 25,768,270 outputs
Outputs from Nature
#13,570
of 98,693 outputs
Outputs of similar age
#5,000
of 326,133 outputs
Outputs of similar age from Nature
#262
of 810 outputs
Altmetric has tracked 25,768,270 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 98,693 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 102.7. This one has done well, scoring higher than 86% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 326,133 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 810 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 67% of its contemporaries.