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Rapid and Sustainable Detoxication of Airborne Pollutants by Broccoli Sprout Beverage: Results of a Randomized Clinical Trial in China

Overview of attention for article published in Cancer Prevention Research, August 2014
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#12 of 1,318)
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (99th percentile)

Mentioned by

news
20 news outlets
blogs
9 blogs
twitter
96 tweeters
patent
2 patents
facebook
21 Facebook pages
wikipedia
1 Wikipedia page
googleplus
4 Google+ users
reddit
1 Redditor
video
5 video uploaders

Citations

dimensions_citation
128 Dimensions

Readers on

mendeley
178 Mendeley
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Title
Rapid and Sustainable Detoxication of Airborne Pollutants by Broccoli Sprout Beverage: Results of a Randomized Clinical Trial in China
Published in
Cancer Prevention Research, August 2014
DOI 10.1158/1940-6207.capr-14-0103
Pubmed ID
Authors

Patricia A. Egner, Jian-Guo Chen, Adam T. Zarth, Derek K. Ng, Jin-Bing Wang, Kevin H. Kensler, Lisa P. Jacobson, Alvaro Muñoz, Jamie L. Johnson, John D. Groopman, Jed W. Fahey, Paul Talalay, Jian Zhu, Tao-Yang Chen, Geng-Sun Qian, Steven G. Carmella, Stephen S. Hecht, Thomas W. Kensler

Abstract

Broccoli sprouts are a convenient and rich source of the glucosinolate, glucoraphanin, which can generate the chemopreventive agent, sulforaphane, an inducer of glutathione S-transferases (GSTs) and other cytoprotective enzymes. A broccoli sprout-derived beverage providing daily doses of 600 µmol glucoraphanin and 40 µmol sulforaphane was evaluated for magnitude and duration of pharmacodynamic action in a 12-week randomized clinical trial. Two hundred and ninety-one study participants were recruited from the rural He-He Township, Qidong, in the Yangtze River delta region of China, an area characterized by exposures to substantial levels of airborne pollutants. Exposure to air pollution has been associated with lung cancer and cardiopulmonary diseases. Urinary excretion of the mercapturic acids of the pollutants, benzene, acrolein, and crotonaldehyde, were measured before and during the intervention using liquid chromatography tandem mass spectrometry. Rapid and sustained, statistically significant (p ≤ 0.01) increases in the levels of excretion of the glutathione-derived conjugates of benzene (61%), acrolein (23%), but not crotonaldehyde were found in those receiving broccoli sprout beverage compared with placebo. Excretion of the benzene-derived mercapturic acid was higher in participants who were GSTT1-positive compared to the null genotype, irrespective of study arm assignment. Measures of sulforaphane metabolites in urine indicated that bioavailability did not decline over the 12-week daily dosing period. Thus, intervention with broccoli sprouts enhances the detoxication of some airborne pollutants and may provide a frugal means to attenuate their associated long-term health risks.

Twitter Demographics

The data shown below were collected from the profiles of 96 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 178 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 1%
Japan 1 <1%
Australia 1 <1%
Unknown 174 98%

Demographic breakdown

Readers by professional status Count As %
Researcher 42 24%
Student > Master 29 16%
Student > Bachelor 20 11%
Student > Ph. D. Student 19 11%
Other 16 9%
Other 25 14%
Unknown 27 15%
Readers by discipline Count As %
Medicine and Dentistry 49 28%
Nursing and Health Professions 18 10%
Biochemistry, Genetics and Molecular Biology 17 10%
Agricultural and Biological Sciences 15 8%
Pharmacology, Toxicology and Pharmaceutical Science 12 7%
Other 29 16%
Unknown 38 21%

Attention Score in Context

This research output has an Altmetric Attention Score of 289. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 August 2022.
All research outputs
#90,405
of 21,752,314 outputs
Outputs from Cancer Prevention Research
#12
of 1,318 outputs
Outputs of similar age
#783
of 206,506 outputs
Outputs of similar age from Cancer Prevention Research
#1
of 21 outputs
Altmetric has tracked 21,752,314 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,318 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 16.6. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 206,506 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 21 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.