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Mitohormesis: Promoting Health and Lifespan by Increased Levels of Reactive Oxygen Species (ROS)

Overview of attention for article published in Dose-Response, January 2014
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • One of the highest-scoring outputs from this source (#9 of 479)
  • High Attention Score compared to outputs of the same age (98th percentile)

Mentioned by

7 news outlets
3 blogs
55 tweeters
2 Facebook pages
1 Wikipedia page
6 Google+ users
1 video uploader


359 Dimensions

Readers on

445 Mendeley
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Mitohormesis: Promoting Health and Lifespan by Increased Levels of Reactive Oxygen Species (ROS)
Published in
Dose-Response, January 2014
DOI 10.2203/dose-response.13-035.ristow
Pubmed ID

Michael Ristow, Kathrin Schmeisser


Increasing evidence indicates that reactive oxygen species (ROS), consisting of superoxide, hydrogen peroxide, and multiple others, do not only cause oxidative stress, but rather may function as signaling molecules that promote health by preventing or delaying a number of chronic diseases, and ultimately extend lifespan. While high levels of ROS are generally accepted to cause cellular damage and to promote aging, low levels of these may rather improve systemic defense mechanisms by inducing an adaptive response. This concept has been named mitochondrial hormesis or mitohormesis. We here evaluate and summarize more than 500 publications from current literature regarding such ROS-mediated low-dose signaling events, including calorie restriction, hypoxia, temperature stress, and physical activity, as well as signaling events downstream of insulin/IGF-1 receptors, AMP-dependent kinase (AMPK), target-of-rapamycin (TOR), and lastly sirtuins to culminate in control of proteostasis, unfolded protein response (UPR), stem cell maintenance and stress resistance. Additionally, consequences of interfering with such ROS signals by pharmacological or natural compounds are being discussed, concluding that particularly antioxidants are useless or even harmful.

Twitter Demographics

The data shown below were collected from the profiles of 55 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 445 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 3 <1%
Germany 2 <1%
Spain 2 <1%
France 1 <1%
Brazil 1 <1%
Denmark 1 <1%
Chile 1 <1%
Belgium 1 <1%
Serbia 1 <1%
Other 0 0%
Unknown 432 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 81 18%
Researcher 68 15%
Student > Master 66 15%
Student > Bachelor 50 11%
Student > Doctoral Student 25 6%
Other 73 16%
Unknown 82 18%
Readers by discipline Count As %
Agricultural and Biological Sciences 91 20%
Biochemistry, Genetics and Molecular Biology 89 20%
Medicine and Dentistry 50 11%
Neuroscience 25 6%
Sports and Recreations 13 3%
Other 68 15%
Unknown 109 24%

Attention Score in Context

This research output has an Altmetric Attention Score of 116. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 May 2023.
All research outputs
of 23,979,422 outputs
Outputs from Dose-Response
of 479 outputs
Outputs of similar age
of 313,877 outputs
Outputs of similar age from Dose-Response
of 4 outputs
Altmetric has tracked 23,979,422 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 479 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.2. This one has done particularly well, scoring higher than 98% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 313,877 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 4 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them