Title |
A human-specific allelic group of the MHC DRB1 gene in primates
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Published in |
Journal of Physiological Anthropology, June 2014
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DOI | 10.1186/1880-6805-33-14 |
Pubmed ID | |
Authors |
Yoshiki Yasukochi, Yoko Satta |
Abstract |
Diversity among human leukocyte antigen (HLA) molecules has been maintained by host-pathogen coevolution over a long period of time. Reflecting this diversity, the HLA loci are the most polymorphic in the human genome. One characteristic of HLA diversity is long-term persistence of allelic lineages, which causes trans-species polymorphisms to be shared among closely related species. Modern humans have disseminated across the world after their exodus from Africa, while chimpanzees have remained in Africa since the speciation event between humans and chimpanzees. It is thought that modern humans have recently acquired resistance to novel pathogens outside Africa. In the present study, we investigated HLA alleles that could contribute to this local adaptation in humans and also studied the contribution of natural selection to human evolution by using molecular data. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 3 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 3 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Japan | 1 | 4% |
Germany | 1 | 4% |
Brazil | 1 | 4% |
Unknown | 24 | 89% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 7 | 26% |
Student > Master | 5 | 19% |
Student > Ph. D. Student | 4 | 15% |
Student > Doctoral Student | 2 | 7% |
Professor | 2 | 7% |
Other | 2 | 7% |
Unknown | 5 | 19% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 12 | 44% |
Biochemistry, Genetics and Molecular Biology | 5 | 19% |
Computer Science | 1 | 4% |
Immunology and Microbiology | 1 | 4% |
Unknown | 8 | 30% |