Title |
Irinotecan induces steroid and xenobiotic receptor (SXR) signaling to detoxification pathway in colon cancer cells
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Published in |
Molecular Cancer, July 2011
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DOI | 10.1186/1476-4598-10-80 |
Pubmed ID | |
Authors |
Agnes Basseville, Laurence Preisser, Sophie de Carné Trécesson, Michèle Boisdron-Celle, Erick Gamelin, Olivier Coqueret, Alain Morel |
Abstract |
Resistance to chemotherapy remains one of the principle obstacles to the treatment of colon cancer. In order to identify the molecular mechanism of this resistance, we investigated the role of the steroid and xenobiotic receptor (SXR) in the induction of drug resistance. Indeed, this nuclear receptor plays an important role in response to xenobiotics through the upregulation of detoxification genes. Following drug treatments, SXR is activated and interacts with the retinoid X receptor (RXR) to induce expression of some genes involved in drug metabolism such as phase I enzyme (like CYP), phase II enzymes (like UGT) and transporters (e.g. MDR1). |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Canada | 1 | 2% |
Unknown | 47 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 10 | 21% |
Researcher | 9 | 19% |
Student > Master | 5 | 10% |
Other | 3 | 6% |
Student > Bachelor | 3 | 6% |
Other | 7 | 15% |
Unknown | 11 | 23% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 16 | 33% |
Agricultural and Biological Sciences | 14 | 29% |
Medicine and Dentistry | 4 | 8% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 4% |
Immunology and Microbiology | 1 | 2% |
Other | 1 | 2% |
Unknown | 10 | 21% |