RT @SAOscience: In a 2017 paper in @FrontiersIn, @blarodlo13 showed "that human in silico drug trials constitute a powerful methodology for…
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In a 2017 paper in @FrontiersIn, @blarodlo13 showed "that human in silico drug trials constitute a powerful methodology for prediction of clinical pro-arrhythmic cardiotoxicity, ready for integration in the existing drug safety assessment pipelines." 9/ ht
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All drugs with high TdP risk were correctly identified as risky with the RA-based classification in the in silico population. 5 drugs with possible/conditional TdP risk resulted as false negatives: Clozapine, Dasatinib, Paroxetine, Saquinavir, Voriconazole
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