Title |
Complex role of HIF in cancer: the known, the unknown, and the unexpected
|
---|---|
Published in |
Hypoxia, June 2014
|
DOI | 10.2147/hp.s50651 |
Pubmed ID | |
Authors |
Patricia Denise Tiburcio, Hyunsung Choi, L Eric Huang |
Abstract |
Tumor hypoxia has long been recognized as a driving force of malignant progression and therapeutic resistance. The discovery of hypoxia-inducible transcription factors (HIFs) has greatly advanced our understanding of how cancer cells cope with hypoxic stress by maintaining bioenergetics through the stimulation of glycolysis. Until recently, however, it remained perplexing why proliferative cancer cells opt for aerobic glycolysis, an energy-inefficient process of glucose metabolism. Furthermore, the role of HIF in cancer has also become complex. In this review, we highlight recent groundbreaking findings in cancer metabolism, put forward plausible explanations to the complex role of HIF, and underscore remaining issues in cancer biology. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Practitioners (doctors, other healthcare professionals) | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 3% |
Unknown | 35 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 6 | 17% |
Researcher | 5 | 14% |
Student > Doctoral Student | 4 | 11% |
Student > Bachelor | 4 | 11% |
Student > Master | 4 | 11% |
Other | 4 | 11% |
Unknown | 9 | 25% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 9 | 25% |
Agricultural and Biological Sciences | 7 | 19% |
Medicine and Dentistry | 4 | 11% |
Neuroscience | 2 | 6% |
Sports and Recreations | 2 | 6% |
Other | 3 | 8% |
Unknown | 9 | 25% |