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Identification of longitudinally dynamic biomarkers in Alzheimer’s disease cerebrospinal fluid by targeted proteomics

Overview of attention for article published in Molecular Neurodegeneration, June 2014
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  • Good Attention Score compared to outputs of the same age (74th percentile)
  • High Attention Score compared to outputs of the same age and source (80th percentile)

Mentioned by

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3 X users
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1 patent

Citations

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110 Dimensions

Readers on

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143 Mendeley
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Title
Identification of longitudinally dynamic biomarkers in Alzheimer’s disease cerebrospinal fluid by targeted proteomics
Published in
Molecular Neurodegeneration, June 2014
DOI 10.1186/1750-1326-9-22
Pubmed ID
Authors

Kristin R Wildsmith, Stephen P Schauer, Ashley M Smith, David Arnott, Yuda Zhu, Joshua Haznedar, Surinder Kaur, W Rodney Mathews, Lee A Honigberg

Abstract

Alzheimer's disease (AD) is the leading cause of dementia affecting greater than 26 million people worldwide. Although cerebrospinal fluid (CSF) levels of Aβ42, tau, and p-tau181 are well established as diagnostic biomarkers of AD, there is a need for additional CSF biomarkers of neuronal function that continue to change during disease progression and could be used as pharmacodynamic measures in clinical trials. Multiple proteomic discovery experiments have reported a range of CSF biomarkers that differ between AD and control subjects. These potential biomarkers represent multiple aspects of the disease pathology. The performance of these markers has not been compared with each other, and their performance has not been evaluated longitudinally.

X Demographics

X Demographics

The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 143 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Denmark 3 2%
United States 2 1%
Netherlands 1 <1%
Belgium 1 <1%
Australia 1 <1%
Greece 1 <1%
Spain 1 <1%
Unknown 133 93%

Demographic breakdown

Readers by professional status Count As %
Researcher 32 22%
Student > Ph. D. Student 28 20%
Student > Master 18 13%
Professor > Associate Professor 8 6%
Student > Bachelor 7 5%
Other 18 13%
Unknown 32 22%
Readers by discipline Count As %
Agricultural and Biological Sciences 24 17%
Biochemistry, Genetics and Molecular Biology 19 13%
Medicine and Dentistry 18 13%
Neuroscience 17 12%
Chemistry 7 5%
Other 22 15%
Unknown 36 25%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 September 2022.
All research outputs
#6,754,462
of 25,374,647 outputs
Outputs from Molecular Neurodegeneration
#673
of 977 outputs
Outputs of similar age
#59,613
of 242,856 outputs
Outputs of similar age from Molecular Neurodegeneration
#2
of 10 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one has received more attention than most of these and is in the 73rd percentile.
So far Altmetric has tracked 977 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 16.6. This one is in the 30th percentile – i.e., 30% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 242,856 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 74% of its contemporaries.
We're also able to compare this research output to 10 others from the same source and published within six weeks on either side of this one. This one has scored higher than 8 of them.