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A new sensitive PCR assay for one-step detection of 12 IDH1/2 mutations in glioma

Overview of attention for article published in Acta Neuropathologica Communications, June 2014
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (80th percentile)
  • High Attention Score compared to outputs of the same age and source (85th percentile)

Mentioned by

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1 tweeter
patent
3 patents

Citations

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34 Dimensions

Readers on

mendeley
43 Mendeley

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Summary Twitter Patents Dimensions citations
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Title
A new sensitive PCR assay for one-step detection of 12 IDH1/2 mutations in glioma
Published in
Acta Neuropathologica Communications, June 2014
DOI 10.1186/2051-5960-2-58
Pubmed ID
24889502
Authors

Aurélie Catteau, Hélène Girardi, Florence Monville, Cécile Poggionovo, Sabrina Carpentier, Véronique Frayssinet, Jesse Voss, Robert Jenkins, Blandine Boisselier, Karima Mokhtari, Marc Sanson, Hélène Peyro-Saint-Paul, Caterina Giannini

Abstract

Mutations in isocitrate dehydrogenase genes IDH1 or IDH2 are frequent in glioma, and IDH mutation status is a strong diagnostic and prognostic marker. Current IDH mutation screening is performed with an immunohistochemistry (IHC) assay specific for IDH1 R132H, the most common mutation. Sequencing is recommended as a second-step test for IHC-negative or -equivocal cases. We developed and validated a new real-time quantitative polymerase chain reaction (PCR) assay for single-step detection of IDH1 R132H and 11 rare IDH1/2 mutations in formalin-fixed paraffin-embedded (FFPE) glioma samples. Performance of the IDH1/2 PCR assay was compared to IHC and Sanger sequencing.

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Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 43 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 2%
Unknown 42 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 7 16%
Researcher 7 16%
Student > Doctoral Student 5 12%
Student > Bachelor 5 12%
Other 4 9%
Other 8 19%
Unknown 7 16%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 17 40%
Medicine and Dentistry 12 28%
Agricultural and Biological Sciences 3 7%
Pharmacology, Toxicology and Pharmaceutical Science 1 2%
Nursing and Health Professions 1 2%
Other 0 0%
Unknown 9 21%

Attention Score in Context

This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 April 2020.
All research outputs
#4,506,719
of 22,757,541 outputs
Outputs from Acta Neuropathologica Communications
#842
of 1,369 outputs
Outputs of similar age
#44,481
of 227,119 outputs
Outputs of similar age from Acta Neuropathologica Communications
#3
of 21 outputs
Altmetric has tracked 22,757,541 research outputs across all sources so far. Compared to these this one has done well and is in the 80th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,369 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 12.8. This one is in the 38th percentile – i.e., 38% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 227,119 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 80% of its contemporaries.
We're also able to compare this research output to 21 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 85% of its contemporaries.

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