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Mendeley readers
Attention Score in Context
| Title |
Beyond the Chromosome: The Prevalence of Unique Extra-Chromosomal Bacteriophages with Integrated Virulence Genes in Pathogenic Staphylococcus aureus
|
|---|---|
| Published in |
PLOS ONE, June 2014
|
| DOI | 10.1371/journal.pone.0100502 |
| Pubmed ID | |
| Authors |
Bryan Utter, Douglas R. Deutsch, Raymond Schuch, Benjamin Y. Winer, Kathleen Verratti, Kim Bishop-Lilly, Shanmuga Sozhamannan, Vincent A. Fischetti |
| Abstract |
In Staphylococcus aureus, the disease impact of chromosomally integrated prophages on virulence is well described. However, the existence of extra-chromosomal prophages, both plasmidial and episomal, remains obscure. Despite the recent explosion in bacterial and bacteriophage genomic sequencing, studies have failed to specifically focus on extra-chromosomal elements. We selectively enriched and sequenced extra-chromosomal DNA from S. aureus isolates using Roche-454 technology and uncovered evidence for the widespread distribution of multiple extra-chromosomal prophages (ExPΦs) throughout both antibiotic-sensitive and -resistant strains. We completely sequenced one such element comprised of a 43.8 kbp, circular ExPΦ (designated ФBU01) from a vancomycin-intermediate S. aureus (VISA) strain. Assembly and annotation of ФBU01 revealed a number of putative virulence determinants encoded within a bacteriophage immune evasion cluster (IEC). Our identification of several potential ExPΦs and mobile genetic elements (MGEs) also revealed numerous putative virulence factors and antibiotic resistance genes. We describe here a previously unidentified level of genetic diversity of stealth extra-chromosomal elements in S. aureus, including phages with a larger presence outside the chromosome that likely play a prominent role in pathogenesis and strain diversity driven by horizontal gene transfer (HGT). |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 86 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| China | 1 | 1% |
| France | 1 | 1% |
| Germany | 1 | 1% |
| Brazil | 1 | 1% |
| Unknown | 82 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 18 | 21% |
| Student > Ph. D. Student | 14 | 16% |
| Student > Master | 12 | 14% |
| Student > Bachelor | 12 | 14% |
| Professor > Associate Professor | 4 | 5% |
| Other | 12 | 14% |
| Unknown | 14 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 29 | 34% |
| Biochemistry, Genetics and Molecular Biology | 17 | 20% |
| Immunology and Microbiology | 15 | 17% |
| Environmental Science | 2 | 2% |
| Nursing and Health Professions | 1 | 1% |
| Other | 3 | 3% |
| Unknown | 19 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 63. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 September 2023.
All research outputs
#641,863
of 24,453,338 outputs
Outputs from PLOS ONE
#8,809
of 211,103 outputs
Outputs of similar age
#6,080
of 232,780 outputs
Outputs of similar age from PLOS ONE
#197
of 4,411 outputs
Altmetric has tracked 24,453,338 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 211,103 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.6. This one has done particularly well, scoring higher than 95% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 232,780 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 4,411 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 95% of its contemporaries.