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Factors Determining Immunological Response to Vaccination against Tick-Borne Encephalitis Virus in Older Individuals.

Overview of attention for article published in PLoS ONE, June 2014
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3 tweeters

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6 Mendeley
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Title
Factors Determining Immunological Response to Vaccination against Tick-Borne Encephalitis Virus in Older Individuals.
Published in
PLoS ONE, June 2014
DOI 10.1371/journal.pone.0100860
Pubmed ID
Authors

Pontus Lindblom, Peter Wilhelmsson, Linda Fryland, Andreas Matussek, Mats Haglund, Johanna Sjöwall, Sirkka Vene, Dag Nyman, Pia Forsberg, Per-Eric Lindgren

Abstract

We performed a cross-sectional study including 533 individuals (median age 61) from the highly TBE endemic Åland Islands in the archipelago between Sweden and Finland. Blood samples, questionnaires and vaccination records were obtained from all study participants. The aim was to investigate if there was any association between TBEV antibody titer and 12 health-related factors. Measurement of TBEV IgG antibodies was performed using two commercial ELISA assays (Enzygnost and Immunozym), and a third in-house rapid fluorescent focus inhibition test was used to measure TBEV neutralizing antibodies. The age of the individual and the number of vaccine doses were the two most important factors determining the immunological response to vaccination. The response to each vaccine dose declined linearly with increased age. A 35 year age difference corresponds to a vaccine dose increment from 3 to 4 to achieve the same immunological response. Participants previously vaccinated against other flaviviruses had lower odds of being seropositive for neutralizing TBEV antibodies on average, while participants with self-reported asthma had higher odds of being seropositive. By comparing the 3 serological assays we show that the Enzygnost and Immunozym assay differ due to choice of cutoffs, but not in overall accuracy.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 6 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 17%
Unknown 5 83%

Demographic breakdown

Readers by professional status Count As %
Researcher 2 33%
Student > Doctoral Student 2 33%
Other 1 17%
Professor > Associate Professor 1 17%
Readers by discipline Count As %
Medicine and Dentistry 3 50%
Agricultural and Biological Sciences 1 17%
Immunology and Microbiology 1 17%
Social Sciences 1 17%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 June 2014.
All research outputs
#2,738,333
of 5,569,395 outputs
Outputs from PLoS ONE
#49,349
of 95,620 outputs
Outputs of similar age
#61,012
of 133,036 outputs
Outputs of similar age from PLoS ONE
#1,464
of 2,612 outputs
Altmetric has tracked 5,569,395 research outputs across all sources so far. This one is in the 47th percentile – i.e., 47% of other outputs scored the same or lower than it.
So far Altmetric has tracked 95,620 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.6. This one is in the 43rd percentile – i.e., 43% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 133,036 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 50% of its contemporaries.
We're also able to compare this research output to 2,612 others from the same source and published within six weeks on either side of this one. This one is in the 40th percentile – i.e., 40% of its contemporaries scored the same or lower than it.