Title |
Fast Separation, Characterization, and Speciation of Gold and Silver Nanoparticles and Their Ionic Counterparts with Micellar Electrokinetic Chromatography Coupled to ICP-MS
|
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Published in |
Analytical Chemistry, June 2014
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DOI | 10.1021/ac403998e |
Pubmed ID | |
Authors |
Bastian Franze, Carsten Engelhard |
Abstract |
In this study, a method for separation, size characterization, and speciation of gold and silver nanoparticles was developed through the use of micellar electrokinetic chromatography (MEKC) coupled to inductively coupled plasma-mass spectrometry (ICP-MS) for the first time. Figures of merit in this proof-of-principle study include peak area precision of 4-6%, stable migration times (1.4% with internal standard), and capillary recoveries on the order of 72-100% depending on species and nanoparticle size, respectively. Detection limits are currently in the sub-microgram per liter range. For example, a total of 1500 50-nm-sized gold nanoparticles were successfully detected. After careful optimization, MEKC-ICP-MS was used to separate engineered nanoparticles (ENPs) of different composition. Speciation analysis of ENPs and free metal ions in solution was feasible using a complexing agent (penicillamine). Gold speciation analysis of a dietary supplement, which contained approximately 6-nm-sized gold nanoparticles, was demonstrated. |
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Demographic breakdown
Type | Count | As % |
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Scientists | 2 | 100% |
Mendeley readers
Geographical breakdown
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Spain | 1 | 1% |
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Demographic breakdown
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Student > Ph. D. Student | 29 | 31% |
Researcher | 12 | 13% |
Professor > Associate Professor | 9 | 10% |
Student > Master | 9 | 10% |
Student > Postgraduate | 6 | 6% |
Other | 12 | 13% |
Unknown | 17 | 18% |
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Environmental Science | 8 | 9% |
Agricultural and Biological Sciences | 5 | 5% |
Engineering | 4 | 4% |
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Other | 7 | 7% |
Unknown | 26 | 28% |