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Intracranial Hemorrhage and Novel Anticoagulants for Atrial Fibrillation: What Have We Learned?

Overview of attention for article published in Current Cardiology Reports, March 2014
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Title
Intracranial Hemorrhage and Novel Anticoagulants for Atrial Fibrillation: What Have We Learned?
Published in
Current Cardiology Reports, March 2014
DOI 10.1007/s11886-014-0480-9
Pubmed ID
Authors

Graeme J. Hankey

Abstract

Intracranial hemorrhage (ICH) affects 0.2-0.5 % of atrial fibrillation (AF) patients taking a novel oral anticoagulant (NOAC) each year. About two thirds of ICHs are intracerebral and one quarter subdural. The 30-day case fatality of NOAC-associated ICH was similar to that of warfarin-associated ICH in two trials. Consistent predictors of ICH are increasing age, a history of prior stroke or TIA, and concomitant use of an antiplatelet drug. Compared to warfarin, the NOACs significantly reduce the risk of ICH by half (risk ratio = 0.44; 95 % CI: 0.37 to 0.51). Compared to aspirin, apixaban has a similar risk of ICH (risk ratio = 0.84; 95 % CI, 0.38 to 1.87). Current treatments for NOAC-associated ICH include nonactivated and activated prothrombin complex concentrate, which reverse the anticoagulant effects of the NOACs, but their effects on bleeding and patient outcome are not known. Future treatments for NOAC-associated ICH promise to include specific antidotes to dabigatran (e.g., aDabi-Fab, PER977) and factor Xa inhibitors (e.g., r-Antidote PRT064445, PER977).

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 101 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Portugal 1 <1%
Netherlands 1 <1%
Slovenia 1 <1%
Spain 1 <1%
United States 1 <1%
Unknown 96 95%

Demographic breakdown

Readers by professional status Count As %
Researcher 18 18%
Student > Ph. D. Student 15 15%
Student > Master 15 15%
Student > Bachelor 11 11%
Student > Doctoral Student 8 8%
Other 25 25%
Unknown 9 9%
Readers by discipline Count As %
Medicine and Dentistry 68 67%
Pharmacology, Toxicology and Pharmaceutical Science 5 5%
Economics, Econometrics and Finance 2 2%
Neuroscience 2 2%
Nursing and Health Professions 1 <1%
Other 4 4%
Unknown 19 19%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 June 2014.
All research outputs
#18,373,874
of 22,757,541 outputs
Outputs from Current Cardiology Reports
#738
of 995 outputs
Outputs of similar age
#162,102
of 223,376 outputs
Outputs of similar age from Current Cardiology Reports
#12
of 17 outputs
Altmetric has tracked 22,757,541 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 995 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.4. This one is in the 9th percentile – i.e., 9% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 223,376 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 14th percentile – i.e., 14% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 17 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.