Title |
Coordination of Chromosome Segregation and Cell Division in Staphylococcus aureus
|
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Published in |
Frontiers in Microbiology, August 2017
|
DOI | 10.3389/fmicb.2017.01575 |
Pubmed ID | |
Authors |
Amy L. Bottomley, Andrew T. F. Liew, Kennardy D. Kusuma, Elizabeth Peterson, Lisa Seidel, Simon J. Foster, Elizabeth J. Harry |
Abstract |
Productive bacterial cell division and survival of progeny requires tight coordination between chromosome segregation and cell division to ensure equal partitioning of DNA. Unlike rod-shaped bacteria that undergo division in one plane, the coccoid human pathogen Staphylococcus aureus divides in three successive orthogonal planes, which requires a different spatial control compared to rod-shaped cells. To gain a better understanding of how this coordination between chromosome segregation and cell division is regulated in S. aureus, we investigated proteins that associate with FtsZ and the divisome. We found that DnaK, a well-known chaperone, interacts with FtsZ, EzrA and DivIVA, and is required for DivIVA stability. Unlike in several rod shaped organisms, DivIVA in S. aureus associates with several components of the divisome, as well as the chromosome segregation protein, SMC. This data, combined with phenotypic analysis of mutants, suggests a novel role for S. aureus DivIVA in ensuring cell division and chromosome segregation are coordinated. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 3 | 43% |
Australia | 1 | 14% |
United Kingdom | 1 | 14% |
Netherlands | 1 | 14% |
Unknown | 1 | 14% |
Demographic breakdown
Type | Count | As % |
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Scientists | 6 | 86% |
Members of the public | 1 | 14% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 43 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 14 | 33% |
Student > Master | 8 | 19% |
Researcher | 5 | 12% |
Student > Bachelor | 3 | 7% |
Student > Doctoral Student | 3 | 7% |
Other | 2 | 5% |
Unknown | 8 | 19% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 23 | 53% |
Immunology and Microbiology | 6 | 14% |
Agricultural and Biological Sciences | 4 | 9% |
Psychology | 1 | 2% |
Chemistry | 1 | 2% |
Other | 0 | 0% |
Unknown | 8 | 19% |