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Treatment outcomes for isoniazid-resistant tuberculosis under program conditions in British Columbia, Canada

Overview of attention for article published in BMC Infectious Diseases, September 2017
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4 tweeters
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1 Facebook page

Citations

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7 Dimensions

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40 Mendeley
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Title
Treatment outcomes for isoniazid-resistant tuberculosis under program conditions in British Columbia, Canada
Published in
BMC Infectious Diseases, September 2017
DOI 10.1186/s12879-017-2706-0
Pubmed ID
Authors

Kamila Romanowski, Leslie Y. Chiang, David Z. Roth, Mel Krajden, Patrick Tang, Victoria J. Cook, James C. Johnston

Abstract

Every year, over 1 million people develop isoniazid (INH) resistant tuberculosis (TB). Yet, the optimal treatment regimen remains unclear. Given increasing prevalence, the clinical efficacy of regimens used by physicians is of interest. This study aims to examine treatment outcomes of INH resistant TB patients, treated under programmatic conditions in British Columbia, Canada. Medical charts were retrospectively reviewed for cases of culture-confirmed INH mono-resistant TB reported to the BC Centre for Disease Control (BCCDC) from 2002 to 2014. Treatment regimens, patient and strain characteristics, and clinical outcomes were analysed. One hundred sixty five cases of INH mono-resistant TB were included in analysis and over 30 different treatment regimens were prescribed. Median treatment duration was 10.5 months (IQR 9-12 months) and treatment was extended beyond 12 months for 26 patients (15.8%). Fifty six patients (22.6%) experienced an adverse event that resulted in a drug regimen modification. Overall, 140 patients (84.8%) had a successful treatment outcome while 12 (7.2%) had an unsuccessful treatment outcome of failure (n = 2; 1.2%), relapse (n = 4; 2.4%) or all cause mortality (n = 6; 3.6%). Our treatment outcomes, while consistent with findings reported from other studies in high resource settings, raise concerns about current recommendations for INH resistant TB treatment. Only a small proportion of patients completed the recommended treatment regimens. High quality studies to confirm the effectiveness of standardized regimens are urgently needed, with special consideration given to trials utilizing fluoroquinolones.

Twitter Demographics

The data shown below were collected from the profiles of 4 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 40 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 40 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 12 30%
Student > Doctoral Student 5 13%
Student > Master 4 10%
Student > Ph. D. Student 4 10%
Student > Postgraduate 2 5%
Other 7 18%
Unknown 6 15%
Readers by discipline Count As %
Medicine and Dentistry 8 20%
Engineering 6 15%
Immunology and Microbiology 5 13%
Nursing and Health Professions 2 5%
Biochemistry, Genetics and Molecular Biology 2 5%
Other 6 15%
Unknown 11 28%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 September 2017.
All research outputs
#8,398,704
of 13,946,582 outputs
Outputs from BMC Infectious Diseases
#2,577
of 5,205 outputs
Outputs of similar age
#144,958
of 269,256 outputs
Outputs of similar age from BMC Infectious Diseases
#1
of 2 outputs
Altmetric has tracked 13,946,582 research outputs across all sources so far. This one is in the 37th percentile – i.e., 37% of other outputs scored the same or lower than it.
So far Altmetric has tracked 5,205 research outputs from this source. They receive a mean Attention Score of 4.8. This one is in the 46th percentile – i.e., 46% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 269,256 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 42nd percentile – i.e., 42% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 2 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them