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Non-invasive multimodal functional imaging of the intestine with frozen micellar naphthalocyanines

Overview of attention for article published in Nature Nanotechnology, July 2014
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#28 of 2,795)
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (96th percentile)

Mentioned by

news
32 news outlets
blogs
12 blogs
twitter
5 tweeters
patent
2 patents

Citations

dimensions_citation
239 Dimensions

Readers on

mendeley
107 Mendeley
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Title
Non-invasive multimodal functional imaging of the intestine with frozen micellar naphthalocyanines
Published in
Nature Nanotechnology, July 2014
DOI 10.1038/nnano.2014.130
Pubmed ID
Authors

Yumiao Zhang, Mansik Jeon, Laurie J. Rich, Hao Hong, Jumin Geng, Yin Zhang, Sixiang Shi, Todd E. Barnhart, Paschalis Alexandridis, Jan D. Huizinga, Mukund Seshadri, Weibo Cai, Chulhong Kim, Jonathan F. Lovell

Abstract

There is a need for safer and improved methods for non-invasive imaging of the gastrointestinal tract. Modalities based on X-ray radiation, magnetic resonance and ultrasound suffer from limitations with respect to safety, accessibility or lack of adequate contrast. Functional intestinal imaging of dynamic gut processes has not been practical using existing approaches. Here, we report the development of a family of nanoparticles that can withstand the harsh conditions of the stomach and intestine, avoid systemic absorption, and provide good optical contrast for photoacoustic imaging. The hydrophobicity of naphthalocyanine dyes was exploited to generate purified ∼ 20 nm frozen micelles, which we call nanonaps, with tunable and large near-infrared absorption values (>1,000). Unlike conventional chromophores, nanonaps exhibit non-shifting spectra at ultrahigh optical densities and, following oral administration in mice, passed safely through the gastrointestinal tract. Non-invasive, non-ionizing photoacoustic techniques were used to visualize nanonap intestinal distribution with low background and remarkable resolution, and enabled real-time intestinal functional imaging with ultrasound co-registration. Positron emission tomography following seamless nanonap radiolabelling allowed complementary whole-body imaging.

Twitter Demographics

The data shown below were collected from the profiles of 5 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 107 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Canada 4 4%
United Kingdom 1 <1%
Unknown 102 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 35 33%
Student > Master 14 13%
Researcher 11 10%
Other 10 9%
Student > Bachelor 9 8%
Other 12 11%
Unknown 16 15%
Readers by discipline Count As %
Chemistry 32 30%
Agricultural and Biological Sciences 15 14%
Materials Science 10 9%
Engineering 7 7%
Biochemistry, Genetics and Molecular Biology 6 6%
Other 18 17%
Unknown 19 18%

Attention Score in Context

This research output has an Altmetric Attention Score of 318. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 December 2019.
All research outputs
#46,022
of 15,306,144 outputs
Outputs from Nature Nanotechnology
#28
of 2,795 outputs
Outputs of similar age
#560
of 189,798 outputs
Outputs of similar age from Nature Nanotechnology
#2
of 58 outputs
Altmetric has tracked 15,306,144 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,795 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 32.9. This one has done particularly well, scoring higher than 98% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 189,798 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 58 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 96% of its contemporaries.