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What the human sperm methylome tells us

Overview of attention for article published in Epigenomics, October 2017
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (71st percentile)
  • Good Attention Score compared to outputs of the same age and source (70th percentile)

Mentioned by

twitter
7 tweeters

Citations

dimensions_citation
6 Dimensions

Readers on

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24 Mendeley
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Title
What the human sperm methylome tells us
Published in
Epigenomics, October 2017
DOI 10.2217/epi-2017-0049
Pubmed ID
Authors

Cristina Camprubí, Riccardo Aiese Cigliano, Albert Salas-Huetos, Nicolas Garrido, Joan Blanco

Abstract

To characterize the sperm methylome in semen samples from 19 donors with proven fertility. Bisulfite-converted sperm DNA was hybridized on the HumanMethylation450 Infinium BeadChip platform. CpG fluorescence intensities were extracted and converted to β-values. The sperm methylome is highly homogeneous and hypomethylated. Genes with hypomethylated promoters are ontologically associated to biological functions related to spermatogenesis and embryogenesis. Sex chromosomes are the most hypomethylated chromosomes, supporting data that indicated their essential role in spermatogenesis. A total of 94 genes are resistant to demethylation, being strong candidates for transgenerational inheritance. Spermatozoa carry a homogeneous methylation profile that is a footprint of past events (spermatogenesis), is designed to facilitate future events (embryogenesis) and has a possible influence in the adult life (transgenerational effects).

Twitter Demographics

The data shown below were collected from the profiles of 7 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 24 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 24 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 8 33%
Researcher 6 25%
Lecturer > Senior Lecturer 2 8%
Professor 1 4%
Student > Doctoral Student 1 4%
Other 4 17%
Unknown 2 8%
Readers by discipline Count As %
Agricultural and Biological Sciences 8 33%
Biochemistry, Genetics and Molecular Biology 6 25%
Medicine and Dentistry 3 13%
Nursing and Health Professions 1 4%
Psychology 1 4%
Other 1 4%
Unknown 4 17%

Attention Score in Context

This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 February 2018.
All research outputs
#2,990,337
of 12,552,783 outputs
Outputs from Epigenomics
#123
of 642 outputs
Outputs of similar age
#74,523
of 264,831 outputs
Outputs of similar age from Epigenomics
#6
of 20 outputs
Altmetric has tracked 12,552,783 research outputs across all sources so far. Compared to these this one has done well and is in the 76th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 642 research outputs from this source. They receive a mean Attention Score of 4.2. This one has done well, scoring higher than 80% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 264,831 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 71% of its contemporaries.
We're also able to compare this research output to 20 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 70% of its contemporaries.