| Chapter title |
Immunosenescence and influenza vaccine efficacy.
|
|---|---|
| Chapter number | 20 |
| Book title |
Vaccines for Pandemic Influenza
|
| Published in |
Current topics in microbiology and immunology, August 2009
|
| DOI | 10.1007/978-3-540-92165-3_20[doi |
| Pubmed ID | |
| Book ISBNs |
978-3-54-092164-6, 978-3-54-092165-3
|
| Authors |
Sambhara, Suryaprakash, McElhaney, Janet E, McElhaney, Janet E., Suryaprakash Sambhara, Janet E. McElhaney |
| Abstract |
A number of protective immune functions decline with age along with physiological and anatomical changes, contributing to the increased susceptibility of older adults to infectious diseases and suboptimal protective immune responses to vaccination. Influenza vaccination is the most cost-effective strategy to prevent complications from influenza viral infections; however, the immunogenicity and effectiveness of currently licensed vaccines in the United States is about 30-50% in preventing complications arising from influenza and preventing death from all causes during winter months in older adults. Hence, it is crucial to understand the molecular mechanisms that lead to immune dysfunction as a function of age so that appropriate strategies can be developed to enhance the disease resistance and immunogenicity of preventive vaccines, including influenza vaccines, for the older adult population. |
