Title |
Cytocompatible Poly(ethylene glycol)‐co‐polycarbonate Hydrogels Cross‐Linked by Copper‐Free, Strain‐Promoted Click Chemistry
|
---|---|
Published in |
Chemistry - An Asian Journal, August 2011
|
DOI | 10.1002/asia.201100411 |
Pubmed ID | |
Authors |
Jianwen Xu, Tera M. Filion, Fioleda Prifti, Jie Song |
Abstract |
Strategies to encapsulate cells in cytocompatible three-dimensional hydrogels with tunable mechanical properties and degradability without harmful gelling conditions are highly desired for regenerative medicine applications. Here we reported a method for preparing poly(ethylene glycol)-co-polycarbonate hydrogels through copper-free, strain-promoted azide-alkyne cycloaddition (SPAAC) click chemistry. Hydrogels with varying mechanical properties were formed by "clicking" azido-functionalized poly(ethylene glycol)-co-polycarbonate macromers with dibenzocyclooctyne-functionalized poly(ethylene glycol) under physiological conditions within minutes. Bone marrow stromal cells encapsulated in these gels exhibited higher cellular viability than those encapsulated in photo-cross-linked poly(ethylene glycol) dimethacrylate. The precise control over the macromer compositions, cytocompatible SPAAC cross-linking, and the degradability of the polycarbonate segments make these hydrogels promising candidates for scaffold and stem cell assisted tissue repair and regeneration. |
X Demographics
As of 1 July 2024, you may notice a temporary increase in the numbers of X profiles with Unknown location. Click here to learn more.
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Science communicators (journalists, bloggers, editors) | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Japan | 1 | 1% |
United States | 1 | 1% |
Unknown | 91 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 27 | 29% |
Student > Master | 16 | 17% |
Student > Bachelor | 8 | 9% |
Student > Doctoral Student | 6 | 6% |
Researcher | 6 | 6% |
Other | 15 | 16% |
Unknown | 15 | 16% |
Readers by discipline | Count | As % |
---|---|---|
Chemistry | 29 | 31% |
Engineering | 18 | 19% |
Materials Science | 11 | 12% |
Chemical Engineering | 5 | 5% |
Medicine and Dentistry | 4 | 4% |
Other | 7 | 8% |
Unknown | 19 | 20% |