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Cytocompatible Poly(ethylene glycol)‐co‐polycarbonate Hydrogels Cross‐Linked by Copper‐Free, Strain‐Promoted Click Chemistry

Overview of attention for article published in Chemistry - An Asian Journal, August 2011
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (85th percentile)
  • High Attention Score compared to outputs of the same age and source (93rd percentile)

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1 X user
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7 patents

Citations

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89 Dimensions

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93 Mendeley
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Title
Cytocompatible Poly(ethylene glycol)‐co‐polycarbonate Hydrogels Cross‐Linked by Copper‐Free, Strain‐Promoted Click Chemistry
Published in
Chemistry - An Asian Journal, August 2011
DOI 10.1002/asia.201100411
Pubmed ID
Authors

Jianwen Xu, Tera M. Filion, Fioleda Prifti, Jie Song

Abstract

Strategies to encapsulate cells in cytocompatible three-dimensional hydrogels with tunable mechanical properties and degradability without harmful gelling conditions are highly desired for regenerative medicine applications. Here we reported a method for preparing poly(ethylene glycol)-co-polycarbonate hydrogels through copper-free, strain-promoted azide-alkyne cycloaddition (SPAAC) click chemistry. Hydrogels with varying mechanical properties were formed by "clicking" azido-functionalized poly(ethylene glycol)-co-polycarbonate macromers with dibenzocyclooctyne-functionalized poly(ethylene glycol) under physiological conditions within minutes. Bone marrow stromal cells encapsulated in these gels exhibited higher cellular viability than those encapsulated in photo-cross-linked poly(ethylene glycol) dimethacrylate. The precise control over the macromer compositions, cytocompatible SPAAC cross-linking, and the degradability of the polycarbonate segments make these hydrogels promising candidates for scaffold and stem cell assisted tissue repair and regeneration.

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X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 93 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Japan 1 1%
United States 1 1%
Unknown 91 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 27 29%
Student > Master 16 17%
Student > Bachelor 8 9%
Student > Doctoral Student 6 6%
Researcher 6 6%
Other 15 16%
Unknown 15 16%
Readers by discipline Count As %
Chemistry 29 31%
Engineering 18 19%
Materials Science 11 12%
Chemical Engineering 5 5%
Medicine and Dentistry 4 4%
Other 7 8%
Unknown 19 20%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 June 2023.
All research outputs
#3,533,264
of 24,495,755 outputs
Outputs from Chemistry - An Asian Journal
#250
of 5,865 outputs
Outputs of similar age
#17,678
of 127,443 outputs
Outputs of similar age from Chemistry - An Asian Journal
#6
of 86 outputs
Altmetric has tracked 24,495,755 research outputs across all sources so far. Compared to these this one has done well and is in the 85th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,865 research outputs from this source. They receive a mean Attention Score of 1.8. This one has done particularly well, scoring higher than 95% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 127,443 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 85% of its contemporaries.
We're also able to compare this research output to 86 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 93% of its contemporaries.