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Cytocompatible Poly(ethylene glycol)-co-polycarbonate Hydrogels Cross-Linked by Copper-Free, Strain-Promoted Click Chemistry

Overview of attention for article published in Chemistry - An Asian Journal, August 2011
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (79th percentile)
  • High Attention Score compared to outputs of the same age and source (95th percentile)

Mentioned by

twitter
1 tweeter
patent
4 patents

Citations

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82 Dimensions

Readers on

mendeley
82 Mendeley
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Title
Cytocompatible Poly(ethylene glycol)-co-polycarbonate Hydrogels Cross-Linked by Copper-Free, Strain-Promoted Click Chemistry
Published in
Chemistry - An Asian Journal, August 2011
DOI 10.1002/asia.201100411
Pubmed ID
Authors

Jianwen Xu, Tera M. Filion, Fioleda Prifti, Jie Song

Abstract

Strategies to encapsulate cells in cytocompatible three-dimensional hydrogels with tunable mechanical properties and degradability without harmful gelling conditions are highly desired for regenerative medicine applications. Here we reported a method for preparing poly(ethylene glycol)-co-polycarbonate hydrogels through copper-free, strain-promoted azide-alkyne cycloaddition (SPAAC) click chemistry. Hydrogels with varying mechanical properties were formed by "clicking" azido-functionalized poly(ethylene glycol)-co-polycarbonate macromers with dibenzocyclooctyne-functionalized poly(ethylene glycol) under physiological conditions within minutes. Bone marrow stromal cells encapsulated in these gels exhibited higher cellular viability than those encapsulated in photo-cross-linked poly(ethylene glycol) dimethacrylate. The precise control over the macromer compositions, cytocompatible SPAAC cross-linking, and the degradability of the polycarbonate segments make these hydrogels promising candidates for scaffold and stem cell assisted tissue repair and regeneration.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 82 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Japan 1 1%
United States 1 1%
Unknown 80 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 23 28%
Student > Master 15 18%
Student > Bachelor 7 9%
Researcher 6 7%
Student > Doctoral Student 5 6%
Other 13 16%
Unknown 13 16%
Readers by discipline Count As %
Chemistry 27 33%
Engineering 13 16%
Materials Science 11 13%
Chemical Engineering 5 6%
Agricultural and Biological Sciences 4 5%
Other 5 6%
Unknown 17 21%

Attention Score in Context

This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 May 2020.
All research outputs
#3,447,159
of 17,719,454 outputs
Outputs from Chemistry - An Asian Journal
#309
of 4,552 outputs
Outputs of similar age
#20,566
of 104,461 outputs
Outputs of similar age from Chemistry - An Asian Journal
#2
of 93 outputs
Altmetric has tracked 17,719,454 research outputs across all sources so far. Compared to these this one has done well and is in the 80th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,552 research outputs from this source. They receive a mean Attention Score of 1.7. This one has done particularly well, scoring higher than 92% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 104,461 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 79% of its contemporaries.
We're also able to compare this research output to 93 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 95% of its contemporaries.