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X Demographics
Mendeley readers
Attention Score in Context
| Title |
HSPA5 is an essential host factor for Ebola virus infection
|
|---|---|
| Published in |
Antiviral Research, July 2014
|
| DOI | 10.1016/j.antiviral.2014.07.004 |
| Pubmed ID | |
| Authors |
St Patrick Reid, Amy C Shurtleff, Julie A Costantino, Sarah R Tritsch, Cary Retterer, Kevin B Spurgers, Sina Bavari |
| Abstract |
Development of novel strategies targeting the highly virulent ebolaviruses is urgently required. A proteomic study identified the ER chaperone HSPA5 as an ebolavirus-associated host protein. Here, we show using the HSPA5 inhibitor (-)- epigallocatechin gallate (EGCG) that the chaperone is essential for virus infection, thereby demonstrating a functional significance for the association. Furthermore, in vitro and in vivo gene targeting impaired viral replication and protected animals in a lethal infection model. These findings demonstrate that HSPA5 is vital for replication and can serve as a viable target for the design of host-based countermeasures. |
X Demographics
The data shown below were collected from the profiles of 13 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 15% |
| United Kingdom | 1 | 8% |
| Pakistan | 1 | 8% |
| Germany | 1 | 8% |
| Unknown | 8 | 62% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 9 | 69% |
| Scientists | 2 | 15% |
| Science communicators (journalists, bloggers, editors) | 1 | 8% |
| Practitioners (doctors, other healthcare professionals) | 1 | 8% |
Mendeley readers
The data shown below were compiled from readership statistics for 91 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Kazakhstan | 1 | 1% |
| United Kingdom | 1 | 1% |
| Canada | 1 | 1% |
| Denmark | 1 | 1% |
| United States | 1 | 1% |
| Angola | 1 | 1% |
| Unknown | 85 | 93% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 19 | 21% |
| Researcher | 19 | 21% |
| Student > Bachelor | 11 | 12% |
| Student > Master | 7 | 8% |
| Other | 7 | 8% |
| Other | 21 | 23% |
| Unknown | 7 | 8% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 27 | 30% |
| Medicine and Dentistry | 11 | 12% |
| Biochemistry, Genetics and Molecular Biology | 8 | 9% |
| Chemistry | 8 | 9% |
| Immunology and Microbiology | 6 | 7% |
| Other | 18 | 20% |
| Unknown | 13 | 14% |
Attention Score in Context
This research output has an Altmetric Attention Score of 26. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 December 2021.
All research outputs
#1,470,353
of 25,374,647 outputs
Outputs from Antiviral Research
#151
of 2,834 outputs
Outputs of similar age
#14,416
of 241,397 outputs
Outputs of similar age from Antiviral Research
#2
of 39 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,834 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 18.5. This one has done particularly well, scoring higher than 94% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 241,397 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 94% of its contemporaries.
We're also able to compare this research output to 39 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 94% of its contemporaries.