Title |
C. albicansgrowth, transition, biofilm formation, and gene expression modulation by antimicrobial decapeptide KSL-W
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Published in |
BMC Microbiology, November 2013
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DOI | 10.1186/1471-2180-13-246 |
Pubmed ID | |
Authors |
Simon Theberge, Abdelhabib Semlali, Abdullah Alamri, Kai P Leung, Mahmoud Rouabhia |
Abstract |
Antimicrobial peptides have been the focus of much research over the last decade because of their effectiveness and broad-spectrum activity against microbial pathogens. These peptides also participate in inflammation and the innate host defense system by modulating the immune function that promotes immune cell adhesion and migration as well as the respiratory burst, which makes them even more attractive as therapeutic agents. This has led to the synthesis of various antimicrobial peptides, including KSL-W (KKVVFWVKFK-NH2), for potential clinical use. Because this peptide displays antimicrobial activity against bacteria, we sought to determine its antifungal effect on C. albicans. Growth, hyphal form, biofilm formation, and degradation were thus examined along with EFG1, NRG1, EAP1, HWP1, and SAP 2-4-5-6 gene expression by quantitative RT-PCR. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 94 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 12 | 13% |
Researcher | 10 | 11% |
Student > Ph. D. Student | 9 | 10% |
Student > Bachelor | 8 | 9% |
Student > Postgraduate | 7 | 7% |
Other | 14 | 15% |
Unknown | 34 | 36% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 19 | 20% |
Medicine and Dentistry | 11 | 12% |
Biochemistry, Genetics and Molecular Biology | 9 | 10% |
Immunology and Microbiology | 5 | 5% |
Veterinary Science and Veterinary Medicine | 2 | 2% |
Other | 7 | 7% |
Unknown | 41 | 44% |