Title |
Ketamine administration in depressive disorders: a systematic review and meta-analysis
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Published in |
Psychopharmacology, July 2014
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DOI | 10.1007/s00213-014-3664-5 |
Pubmed ID | |
Authors |
Guillaume Fond, Anderson Loundou, Corentin Rabu, Alexandra Macgregor, Christophe Lançon, Marie Brittner, Jean-Arthur Micoulaud-Franchi, Raphaelle Richieri, Philippe Courtet, Mocrane Abbar, Matthieu Roger, Marion Leboyer, Laurent Boyer |
Abstract |
Ketamine's efficacy in depressive disorders has been established in several controlled trials. The aim of the present study was to determine whether or not ketamine administration significantly improves depressive symptomatology in depression and more specifically in major depressive disorder (MDD), bipolar depression, resistant depression (non-ECT studies), and as an anesthetic agent in electroconvulsive therapy (ECT) for resistant depression (ECT studies). Secondary outcomes were the duration of ketamine's effect, the efficacy on suicidal ideations, the existence of a dose effect, and the safety/tolerance of the treatment. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Spain | 4 | 21% |
United Kingdom | 2 | 11% |
United States | 2 | 11% |
Denmark | 1 | 5% |
Unknown | 10 | 53% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 14 | 74% |
Scientists | 4 | 21% |
Science communicators (journalists, bloggers, editors) | 1 | 5% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | <1% |
Ireland | 1 | <1% |
Canada | 1 | <1% |
Brazil | 1 | <1% |
Unknown | 477 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 75 | 16% |
Researcher | 58 | 12% |
Student > Master | 57 | 12% |
Other | 40 | 8% |
Student > Ph. D. Student | 37 | 8% |
Other | 103 | 21% |
Unknown | 111 | 23% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 147 | 31% |
Psychology | 51 | 11% |
Neuroscience | 46 | 10% |
Agricultural and Biological Sciences | 24 | 5% |
Pharmacology, Toxicology and Pharmaceutical Science | 22 | 5% |
Other | 51 | 11% |
Unknown | 140 | 29% |