Title |
SYNbiotics Easing Renal failure by improving Gut microbiologY (SYNERGY): a protocol of placebo-controlled randomised cross-over trial
|
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Published in |
BMC Nephrology, July 2014
|
DOI | 10.1186/1471-2369-15-106 |
Pubmed ID | |
Authors |
Megan Rossi, David W Johnson, Mark Morrison, Elaine Pascoe, Jeff S Coombes, Josephine M Forbes, Brett C McWhinney, Jacobus PJ Ungerer, Goce Dimeski, Katrina L Campbell |
Abstract |
Emerging evidence suggests modulating the microbiota in the large bowel of patients with chronic kidney disease (CKD) through pre- and/probiotic supplementation may inhibit the development of key nephrovascular toxins. To date, quality intervention trials investigating this novel treatment in CKD are lacking. The aim of SYNERGY is to assess the effectiveness of synbiotics (co-administration of pre- and probiotics) as a potential treatment targeting the synthesis of uremic toxins, specifically, indoxyl sulphate (IS) and p-cresyl sulphate (PCS). |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 33% |
India | 1 | 33% |
United Kingdom | 1 | 33% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 67% |
Science communicators (journalists, bloggers, editors) | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Russia | 1 | <1% |
Denmark | 1 | <1% |
Slovenia | 1 | <1% |
Australia | 1 | <1% |
Unknown | 152 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 26 | 17% |
Student > Bachelor | 20 | 13% |
Researcher | 13 | 8% |
Student > Postgraduate | 13 | 8% |
Student > Ph. D. Student | 11 | 7% |
Other | 24 | 15% |
Unknown | 49 | 31% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 44 | 28% |
Nursing and Health Professions | 16 | 10% |
Agricultural and Biological Sciences | 12 | 8% |
Biochemistry, Genetics and Molecular Biology | 10 | 6% |
Sports and Recreations | 4 | 3% |
Other | 17 | 11% |
Unknown | 53 | 34% |