Title |
Treatment of severe neurological deficits with IgG depletion through immunoadsorption in patients with Escherichia coli O104:H4-associated haemolytic uraemic syndrome: a prospective trial
|
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Published in |
The Lancet, September 2011
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DOI | 10.1016/s0140-6736(11)61253-1 |
Pubmed ID | |
Authors |
Andreas Greinacher, Sigrun Friesecke, Peter Abel, Alexander Dressel, Sylvia Stracke, Michael Fiene, Friedlinde Ernst, Kathleen Selleng, Karin Weissenborn, Bernhard MW Schmidt, Mario Schiffer, Stephan B Felix, Markus M Lerch, Jan T Kielstein, Julia Mayerle |
Abstract |
In May 2011, an outbreak of Shiga toxin-producing enterohaemorrhagic E coli O104:H4 in northern Germany led to a high proportion of patients developing post-enteritis haemolytic uraemic syndrome and thrombotic microangiopathy that were unresponsive to therapeutic plasma exchange or complement-blocking antibody (eculizumab). Some patients needed ventilatory support due to severe neurological complications, which arose 1 week after onset of enteritis, suggesting an antibody-mediated mechanism. Therefore, we aimed to assess immunoadsorption as rescue therapy. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 33% |
Japan | 1 | 33% |
Unknown | 1 | 33% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 67% |
Practitioners (doctors, other healthcare professionals) | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Germany | 1 | <1% |
Malaysia | 1 | <1% |
Ethiopia | 1 | <1% |
Czechia | 1 | <1% |
Canada | 1 | <1% |
Japan | 1 | <1% |
United States | 1 | <1% |
Unknown | 101 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 18 | 17% |
Other | 16 | 15% |
Student > Bachelor | 12 | 11% |
Student > Ph. D. Student | 9 | 8% |
Student > Master | 9 | 8% |
Other | 25 | 23% |
Unknown | 19 | 18% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 41 | 38% |
Psychology | 11 | 10% |
Agricultural and Biological Sciences | 8 | 7% |
Biochemistry, Genetics and Molecular Biology | 8 | 7% |
Pharmacology, Toxicology and Pharmaceutical Science | 7 | 6% |
Other | 18 | 17% |
Unknown | 15 | 14% |