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Genomic Models of Short-Term Exposure Accurately Predict Long-Term Chemical Carcinogenicity and Identify Putative Mechanisms of Action

Overview of attention for article published in PLOS ONE, July 2014
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (92nd percentile)
  • High Attention Score compared to outputs of the same age and source (88th percentile)

Mentioned by

news
1 news outlet
twitter
12 X users
facebook
3 Facebook pages

Citations

dimensions_citation
63 Dimensions

Readers on

mendeley
77 Mendeley
citeulike
1 CiteULike
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Title
Genomic Models of Short-Term Exposure Accurately Predict Long-Term Chemical Carcinogenicity and Identify Putative Mechanisms of Action
Published in
PLOS ONE, July 2014
DOI 10.1371/journal.pone.0102579
Pubmed ID
Authors

Daniel Gusenleitner, Scott S. Auerbach, Tisha Melia, Harold F. Gómez, David H. Sherr, Stefano Monti

Abstract

Despite an overall decrease in incidence of and mortality from cancer, about 40% of Americans will be diagnosed with the disease in their lifetime, and around 20% will die of it. Current approaches to test carcinogenic chemicals adopt the 2-year rodent bioassay, which is costly and time-consuming. As a result, fewer than 2% of the chemicals on the market have actually been tested. However, evidence accumulated to date suggests that gene expression profiles from model organisms exposed to chemical compounds reflect underlying mechanisms of action, and that these toxicogenomic models could be used in the prediction of chemical carcinogenicity.

X Demographics

X Demographics

The data shown below were collected from the profiles of 12 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 77 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 2 3%
Mexico 1 1%
United States 1 1%
Brazil 1 1%
Unknown 72 94%

Demographic breakdown

Readers by professional status Count As %
Researcher 15 19%
Student > Ph. D. Student 12 16%
Other 9 12%
Student > Bachelor 6 8%
Student > Doctoral Student 5 6%
Other 13 17%
Unknown 17 22%
Readers by discipline Count As %
Agricultural and Biological Sciences 20 26%
Pharmacology, Toxicology and Pharmaceutical Science 7 9%
Computer Science 7 9%
Medicine and Dentistry 6 8%
Biochemistry, Genetics and Molecular Biology 6 8%
Other 12 16%
Unknown 19 25%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 19. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 October 2017.
All research outputs
#1,865,593
of 24,826,104 outputs
Outputs from PLOS ONE
#23,148
of 215,005 outputs
Outputs of similar age
#18,500
of 234,299 outputs
Outputs of similar age from PLOS ONE
#550
of 4,779 outputs
Altmetric has tracked 24,826,104 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 92nd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 215,005 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.7. This one has done well, scoring higher than 89% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 234,299 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 92% of its contemporaries.
We're also able to compare this research output to 4,779 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 88% of its contemporaries.