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Mendeley readers
Attention Score in Context
| Title |
Altered distribution of the EphA4 kinase in hippocampal brain tissue of patients with Alzheimer’s disease correlates with pathology
|
|---|---|
| Published in |
Acta Neuropathologica Communications, July 2014
|
| DOI | 10.1186/s40478-014-0079-9 |
| Pubmed ID | |
| Authors |
Andrea FN Rosenberger, Annemieke JM Rozemuller, Wiesje M van der Flier, Philip Scheltens, Saskia M van der Vies, Jeroen JM Hoozemans |
| Abstract |
Synaptic dysfunction occurs early in the progression of Alzheimer¿s disease (AD) and correlates with memory decline. There is emerging evidence that deregulation of Erythropoietin-producing hepatocellular (Eph) receptor tyrosine kinases (RTK) signaling contributes to the aberrant synaptic functions associated with neurodegeneration. The Eph receptor A4 is highly expressed in human adult hippocampal brain tissue and was previously linked to cognitive impairment in a transgenic mouse model for AD. Whether EphA4 levels are altered in AD brain remains elusive. Therefore we investigated the protein levels and localization of EphA4 in human hippocampus derived from AD (n¿=¿29) as well as non-demented control cases (n¿=¿19). The total EphA4 protein levels were not changed in AD patients compared to control cases. However, immunohistochemical localization of EphA4 revealed an altered distribution in AD compared to control hippocampus. EphA4 immunoreactivity was observed in plaque-like structures in AD cases. Double-labelling with phosphorylated tau and amyloid beta indicates that EphA4 co-localizes with neuritic plaques in AD. This altered distribution pattern was observed at early stages (Braak stage II) and correlates with the hallmarks of AD pathology suggesting a reduced availability of EphA4 that is likely to contribute to synaptic dysfunction that occurs early in AD. |
Mendeley readers
The data shown below were compiled from readership statistics for 51 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 51 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 12 | 24% |
| Researcher | 9 | 18% |
| Student > Master | 6 | 12% |
| Student > Bachelor | 4 | 8% |
| Student > Doctoral Student | 2 | 4% |
| Other | 9 | 18% |
| Unknown | 9 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 10 | 20% |
| Agricultural and Biological Sciences | 9 | 18% |
| Neuroscience | 9 | 18% |
| Pharmacology, Toxicology and Pharmaceutical Science | 4 | 8% |
| Medicine and Dentistry | 4 | 8% |
| Other | 4 | 8% |
| Unknown | 11 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 July 2014.
All research outputs
#20,233,066
of 22,758,963 outputs
Outputs from Acta Neuropathologica Communications
#1,300
of 1,369 outputs
Outputs of similar age
#191,343
of 226,891 outputs
Outputs of similar age from Acta Neuropathologica Communications
#15
of 18 outputs
Altmetric has tracked 22,758,963 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,369 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 12.8. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 226,891 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 18 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.