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Mendeley readers
Attention Score in Context
| Title |
Advancing islet transplantation: from engraftment to the immune response
|
|---|---|
| Published in |
Diabetologia, August 2011
|
| DOI | 10.1007/s00125-011-2243-0 |
| Pubmed ID | |
| Authors |
R. F. Gibly, J. G. Graham, X. Luo, W. L. Lowe, B. J. Hering, L. D. Shea |
| Abstract |
The promise and progress of islet transplantation for treating type 1 diabetes has been challenged by obstacles to patient accessibility and long-term graft function that may be overcome by integrating emerging technologies in biomaterials, drug delivery and immunomodulation. The hepatic microenvironment and traditional systemic immunosuppression stress the vulnerable islets and contribute to the limited success of transplantation. Locally delivering extracellular matrix proteins and trophic factors can enhance transplantation at extrahepatic sites by promoting islet engraftment, revascularisation and long-term function while avoiding unintended systemic effects. Cell- and cytokine-based therapies for immune cell recruitment and reprogramming can inhibit local and systemic immune system activation that normally attacks transplanted islets. Combined with antigen-specific immunotherapies, states of operational tolerance may be achievable, reducing or eliminating the long-term pharmaceutical burden. Integration of these technologies to enhance engraftment and combat rejection may help to advance the therapeutic efficacy and availability of islet transplantation. |
Mendeley readers
The data shown below were compiled from readership statistics for 125 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | <1% |
| Germany | 1 | <1% |
| Unknown | 123 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 30 | 24% |
| Student > Bachelor | 25 | 20% |
| Student > Master | 13 | 10% |
| Researcher | 12 | 10% |
| Student > Doctoral Student | 10 | 8% |
| Other | 10 | 8% |
| Unknown | 25 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Engineering | 23 | 18% |
| Biochemistry, Genetics and Molecular Biology | 17 | 14% |
| Agricultural and Biological Sciences | 16 | 13% |
| Medicine and Dentistry | 12 | 10% |
| Immunology and Microbiology | 5 | 4% |
| Other | 21 | 17% |
| Unknown | 31 | 25% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 February 2022.
All research outputs
#4,756,893
of 23,025,074 outputs
Outputs from Diabetologia
#2,039
of 5,090 outputs
Outputs of similar age
#25,508
of 121,482 outputs
Outputs of similar age from Diabetologia
#10
of 37 outputs
Altmetric has tracked 23,025,074 research outputs across all sources so far. Compared to these this one has done well and is in the 76th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,090 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 22.7. This one has gotten more attention than average, scoring higher than 53% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 121,482 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 74% of its contemporaries.
We're also able to compare this research output to 37 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 70% of its contemporaries.