Title |
Monocytes and Macrophages in Pregnancy and Pre-Eclampsia
|
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Published in |
Frontiers in immunology, June 2014
|
DOI | 10.3389/fimmu.2014.00298 |
Pubmed ID | |
Authors |
Marijke M. Faas, Floor Spaans, Paul De Vos |
Abstract |
Preeclampsia is an important complication in pregnancy, characterized by hypertension and proteinuria in the second half of pregnancy. Generalized activation of the inflammatory response is thought to play a role in the pathogenesis of pre-eclampsia. Monocytes may play a central role in this inflammatory response. Monocytes are short lived cells that mature in the circulation and invade into tissues upon an inflammatory stimulus and develop into macrophages. Macrophages are abundantly present in the endometrium and play a role in implantation and placentation in normal pregnancy. In pre-eclampsia, these macrophages appear to be present in larger numbers and are also activated. In the present review, we focused on the role of monocytes and macrophages in the pathophysiology of pre-eclampsia. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
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Netherlands | 1 | <1% |
Turkey | 1 | <1% |
Argentina | 1 | <1% |
Unknown | 232 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 40 | 17% |
Student > Master | 36 | 15% |
Student > Bachelor | 33 | 14% |
Researcher | 28 | 12% |
Student > Doctoral Student | 16 | 7% |
Other | 34 | 14% |
Unknown | 48 | 20% |
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Agricultural and Biological Sciences | 37 | 16% |
Biochemistry, Genetics and Molecular Biology | 34 | 14% |
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Engineering | 9 | 4% |
Other | 22 | 9% |
Unknown | 56 | 24% |