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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Anti-biofilm, anti-hemolysis, and anti-virulence activities of black pepper, cananga, myrrh oils, and nerolidol against Staphylococcus aureus
|
|---|---|
| Published in |
Applied Microbiology and Biotechnology, July 2014
|
| DOI | 10.1007/s00253-014-5903-4 |
| Pubmed ID | |
| Authors |
Kayeon Lee, Jin-Hyung Lee, Soon-Il Kim, Moo Hwan Cho, Jintae Lee |
| Abstract |
The long-term usage of antibiotics has resulted in the evolution of multidrug-resistant bacteria. Unlike antibiotics, anti-virulence approaches target bacterial virulence without affecting cell viability, which may be less prone to develop drug resistance. Staphylococcus aureus is a major human pathogen that produces diverse virulence factors, such as α-toxin, which is hemolytic. Also, biofilm formation of S. aureus is one of the mechanisms of its drug resistance. In this study, anti-biofilm screening of 83 essential oils showed that black pepper, cananga, and myrrh oils and their common constituent cis-nerolidol at 0.01 % markedly inhibited S. aureus biofilm formation. Furthermore, the three essential oils and cis-nerolidol at below 0.005 % almost abolished the hemolytic activity of S. aureus. Transcriptional analyses showed that black pepper oil down-regulated the expressions of the α-toxin gene (hla), the nuclease genes, and the regulatory genes. In addition, black pepper, cananga, and myrrh oils and cis-nerolidol attenuated S. aureus virulence in the nematode Caenorhabditis elegans. This study is one of the most extensive on anti-virulence screening using diverse essential oils and provides comprehensive data on the subject. This finding implies other beneficial effects of essential oils and suggests that black pepper, cananga, and myrrh oils have potential use as anti-virulence strategies against persistent S. aureus infections. |
X Demographics
The data shown below were collected from the profiles of 26 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Saudi Arabia | 8 | 31% |
| United States | 3 | 12% |
| Serbia | 1 | 4% |
| Palestine, State of | 1 | 4% |
| United Kingdom | 1 | 4% |
| Unknown | 12 | 46% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 25 | 96% |
| Scientists | 1 | 4% |
Mendeley readers
The data shown below were compiled from readership statistics for 122 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Brazil | 1 | <1% |
| Unknown | 121 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 24 | 20% |
| Student > Master | 14 | 11% |
| Student > Bachelor | 14 | 11% |
| Researcher | 13 | 11% |
| Student > Doctoral Student | 11 | 9% |
| Other | 22 | 18% |
| Unknown | 24 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 36 | 30% |
| Biochemistry, Genetics and Molecular Biology | 15 | 12% |
| Immunology and Microbiology | 12 | 10% |
| Pharmacology, Toxicology and Pharmaceutical Science | 8 | 7% |
| Chemistry | 5 | 4% |
| Other | 13 | 11% |
| Unknown | 33 | 27% |
Attention Score in Context
This research output has an Altmetric Attention Score of 32. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 June 2023.
All research outputs
#1,227,364
of 25,359,594 outputs
Outputs from Applied Microbiology and Biotechnology
#56
of 8,279 outputs
Outputs of similar age
#11,823
of 233,681 outputs
Outputs of similar age from Applied Microbiology and Biotechnology
#3
of 95 outputs
Altmetric has tracked 25,359,594 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 8,279 research outputs from this source. They receive a mean Attention Score of 4.4. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 233,681 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 94% of its contemporaries.
We're also able to compare this research output to 95 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 96% of its contemporaries.