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Ellipticine derivative induces potent cytostatic effect in acute myeloid leukaemia cells

Overview of attention for article published in Investigational New Drugs, August 2014
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1 tweeter

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Title
Ellipticine derivative induces potent cytostatic effect in acute myeloid leukaemia cells
Published in
Investigational New Drugs, August 2014
DOI 10.1007/s10637-014-0140-3
Pubmed ID
Authors

E. G. Russell, E. C. O’Sullivan, C. M. Miller, J. Stanicka, F. O. McCarthy, T. G. Cotter

Abstract

A panel of novel ellipticine isomers were designed and synthesised with the aim of evaluating their anti-cancer effects on selected leukaemia cell lines. A preliminary NCI 60-cell screen demonstrated that these compounds display promising anti-tumour activity across a number of different cell types. We have consequently examined the effect of these derivatives in detail on the Acute Myeloid Leukaemia (AML) cell line, MV4-11. Cell cycle analyses revealed that the compounds had a range of distinctive cell cycle effects. 7-Hydroxyisoellipticine showed the most promise with respect to cytostatic activity. We demonstrated that this compound inhibited proliferation of leukaemia cells by preventing cells from progressing from G2 phase into mitosis over a period of 24 h at a concentration of 5 μM. Our research suggests that this is mediated by an induction of reactive oxygen species (ROS), which in turn activates the DNA damage response pathway. As a result of the activation of p53, cyclin B1 is inhibited. The induction of this pathway leads to apoptosis which is seen at 48 h using the same dose of 7-hydroxyisoellipticine. This study provides for the first time detailed cellular information on the potential use of isoellipticines as chemotherapeutic agents.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 16 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Ecuador 1 6%
Unknown 15 94%

Demographic breakdown

Readers by professional status Count As %
Researcher 8 50%
Student > Master 3 19%
Student > Ph. D. Student 2 13%
Student > Bachelor 1 6%
Student > Doctoral Student 1 6%
Other 1 6%
Readers by discipline Count As %
Agricultural and Biological Sciences 4 25%
Biochemistry, Genetics and Molecular Biology 4 25%
Chemistry 3 19%
Social Sciences 1 6%
Medicine and Dentistry 1 6%
Other 2 13%
Unknown 1 6%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 August 2014.
All research outputs
#7,711,834
of 12,335,419 outputs
Outputs from Investigational New Drugs
#444
of 643 outputs
Outputs of similar age
#102,906
of 202,682 outputs
Outputs of similar age from Investigational New Drugs
#7
of 12 outputs
Altmetric has tracked 12,335,419 research outputs across all sources so far. This one is in the 23rd percentile – i.e., 23% of other outputs scored the same or lower than it.
So far Altmetric has tracked 643 research outputs from this source. They receive a mean Attention Score of 4.5. This one is in the 25th percentile – i.e., 25% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 202,682 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 38th percentile – i.e., 38% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 12 others from the same source and published within six weeks on either side of this one. This one is in the 25th percentile – i.e., 25% of its contemporaries scored the same or lower than it.