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VEGFR-3 controls tip to stalk conversion at vessel fusion sites by reinforcing Notch signalling

Overview of attention for article published in Nature Cell Biology, September 2011
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (84th percentile)
  • Good Attention Score compared to outputs of the same age and source (79th percentile)

Mentioned by

blogs
1 blog
twitter
1 tweeter

Citations

dimensions_citation
221 Dimensions

Readers on

mendeley
281 Mendeley
citeulike
1 CiteULike
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Title
VEGFR-3 controls tip to stalk conversion at vessel fusion sites by reinforcing Notch signalling
Published in
Nature Cell Biology, September 2011
DOI 10.1038/ncb2331
Pubmed ID
Authors

Tuomas Tammela, Georgia Zarkada, Harri Nurmi, Lars Jakobsson, Krista Heinolainen, Denis Tvorogov, Wei Zheng, Claudio A. Franco, Aino Murtomäki, Evelyn Aranda, Naoyuki Miura, Seppo Ylä-Herttuala, Marcus Fruttiger, Taija Mäkinen, Anne Eichmann, Jeffrey W. Pollard, Holger Gerhardt, Kari Alitalo

Abstract

Angiogenesis, the growth of new blood vessels, involves specification of endothelial cells to tip cells and stalk cells, which is controlled by Notch signalling, whereas vascular endothelial growth factor receptor (VEGFR)-2 and VEGFR-3 have been implicated in angiogenic sprouting. Surprisingly, we found that endothelial deletion of Vegfr3, but not VEGFR-3-blocking antibodies, postnatally led to excessive angiogenic sprouting and branching, and decreased the level of Notch signalling, indicating that VEGFR-3 possesses passive and active signalling modalities. Furthermore, macrophages expressing the VEGFR-3 and VEGFR-2 ligand VEGF-C localized to vessel branch points, and Vegfc heterozygous mice exhibited inefficient angiogenesis characterized by decreased vascular branching. FoxC2 is a known regulator of Notch ligand and target gene expression, and Foxc2(+/-);Vegfr3(+/-) compound heterozygosity recapitulated homozygous loss of Vegfr3. These results indicate that macrophage-derived VEGF-C activates VEGFR-3 in tip cells to reinforce Notch signalling, which contributes to the phenotypic conversion of endothelial cells at fusion points of vessel sprouts.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 281 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 3 1%
Germany 2 <1%
Austria 1 <1%
Switzerland 1 <1%
Iran, Islamic Republic of 1 <1%
Belgium 1 <1%
Korea, Republic of 1 <1%
Portugal 1 <1%
Unknown 270 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 79 28%
Researcher 70 25%
Student > Master 30 11%
Student > Bachelor 21 7%
Professor 17 6%
Other 46 16%
Unknown 18 6%
Readers by discipline Count As %
Agricultural and Biological Sciences 137 49%
Biochemistry, Genetics and Molecular Biology 54 19%
Medicine and Dentistry 36 13%
Engineering 12 4%
Neuroscience 5 2%
Other 14 5%
Unknown 23 8%

Attention Score in Context

This research output has an Altmetric Attention Score of 8. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 October 2011.
All research outputs
#1,824,759
of 12,343,748 outputs
Outputs from Nature Cell Biology
#984
of 3,043 outputs
Outputs of similar age
#14,731
of 93,337 outputs
Outputs of similar age from Nature Cell Biology
#13
of 64 outputs
Altmetric has tracked 12,343,748 research outputs across all sources so far. Compared to these this one has done well and is in the 85th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,043 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 13.7. This one has gotten more attention than average, scoring higher than 67% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 93,337 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 84% of its contemporaries.
We're also able to compare this research output to 64 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 79% of its contemporaries.