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Deletion of glucose oxidase changes the pattern of organic acid production in Aspergillus carbonarius

Overview of attention for article published in AMB Express, August 2014
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  • Good Attention Score compared to outputs of the same age and source (66th percentile)

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Title
Deletion of glucose oxidase changes the pattern of organic acid production in Aspergillus carbonarius
Published in
AMB Express, August 2014
DOI 10.1186/s13568-014-0054-7
Pubmed ID
Authors

Lei Yang, Mette Lübeck, Peter S Lübeck

Abstract

Aspergillus carbonarius has potential as a cell factory for the production of different organic acids. At pH 5.5, A.carbonarius accumulates high amounts of gluconic acid when it grows on glucose based medium whereas at low pH, it produces citric acid. The conversion of glucose to gluconic acid is carried out by secretion of the enzyme, glucose oxidase. In this work, the gene encoding glucose oxidase was identified and deleted from A. carbonarius with the aim of changing the carbon flux towards other organic acids. The effect of genetic engineering was examined by testing glucose oxidase deficient (Δgox) mutants for the production of different organic acids in a defined production medium. The results obtained showed that the gluconic acid accumulation was completely inhibited and increased amounts of citric acid, oxalic acid and malic acid were observed in the Δgox mutants.

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The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 46 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Denmark 1 2%
Unknown 45 98%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 12 26%
Student > Master 8 17%
Student > Ph. D. Student 6 13%
Student > Postgraduate 3 7%
Researcher 2 4%
Other 6 13%
Unknown 9 20%
Readers by discipline Count As %
Agricultural and Biological Sciences 14 30%
Biochemistry, Genetics and Molecular Biology 11 24%
Chemical Engineering 3 7%
Engineering 3 7%
Chemistry 2 4%
Other 3 7%
Unknown 10 22%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 August 2014.
All research outputs
#14,198,795
of 22,760,687 outputs
Outputs from AMB Express
#302
of 1,231 outputs
Outputs of similar age
#118,961
of 230,675 outputs
Outputs of similar age from AMB Express
#6
of 18 outputs
Altmetric has tracked 22,760,687 research outputs across all sources so far. This one is in the 35th percentile – i.e., 35% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,231 research outputs from this source. They receive a mean Attention Score of 2.8. This one has gotten more attention than average, scoring higher than 72% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 230,675 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 45th percentile – i.e., 45% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 18 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 66% of its contemporaries.