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Inhibiting AKT Phosphorylation Employing Non-Cytotoxic Anthraquinones Ameliorates TH2 Mediated Allergic Airways Disease and Rhinovirus Exacerbation

Overview of attention for article published in PLOS ONE, November 2013
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Title
Inhibiting AKT Phosphorylation Employing Non-Cytotoxic Anthraquinones Ameliorates TH2 Mediated Allergic Airways Disease and Rhinovirus Exacerbation
Published in
PLOS ONE, November 2013
DOI 10.1371/journal.pone.0079565
Pubmed ID
Authors

Caio Cesar de Souza Alves, Adam Collison, Luke Hatchwell, Maximilian Plank, Matthew Morten, Paul S. Foster, Sebastian L. Johnston, Cristiane França da Costa, Mauro Vieira de Almeida, Henrique Couto Teixeira, Ana Paula Ferreira, Joerg Mattes

Abstract

Severe asthma is associated with T helper (TH) 2 and 17 cell activation, airway neutrophilia and phosphoinositide-3-kinase (PI3K) activation. Asthma exacerbations are commonly caused by rhinovirus (RV) and also associated with PI3K-driven inflammation. Anthraquinone derivatives have been shown to reduce PI3K-mediated AKT phosphorylation in-vitro.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 21 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
South Africa 1 5%
Unknown 20 95%

Demographic breakdown

Readers by professional status Count As %
Other 4 19%
Researcher 3 14%
Student > Ph. D. Student 3 14%
Student > Postgraduate 2 10%
Student > Master 1 5%
Other 1 5%
Unknown 7 33%
Readers by discipline Count As %
Medicine and Dentistry 6 29%
Pharmacology, Toxicology and Pharmaceutical Science 2 10%
Agricultural and Biological Sciences 2 10%
Immunology and Microbiology 1 5%
Biochemistry, Genetics and Molecular Biology 1 5%
Other 2 10%
Unknown 7 33%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 August 2014.
All research outputs
#15,303,896
of 22,760,687 outputs
Outputs from PLOS ONE
#130,437
of 194,199 outputs
Outputs of similar age
#132,424
of 215,461 outputs
Outputs of similar age from PLOS ONE
#3,297
of 5,223 outputs
Altmetric has tracked 22,760,687 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 194,199 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.1. This one is in the 24th percentile – i.e., 24% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 215,461 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 28th percentile – i.e., 28% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 5,223 others from the same source and published within six weeks on either side of this one. This one is in the 29th percentile – i.e., 29% of its contemporaries scored the same or lower than it.