Title |
Return of chloroquine-sensitive Plasmodium falciparum parasites and emergence of chloroquine-resistant Plasmodium vivax in Ethiopia
|
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Published in |
Malaria Journal, June 2014
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DOI | 10.1186/1475-2875-13-244 |
Pubmed ID | |
Authors |
Seleshi Kebede Mekonnen, Abraham Aseffa, Nega Berhe, Tilahun Teklehaymanot, Ronald M Clouse, Tamirat Gebru, Girmay Medhin, Thirumalaisamy P Velavan |
Abstract |
Increased resistance by Plasmodium falciparum parasites led to the withdrawal of the antimalarial drugs chloroquine and sulphadoxine-pyrimethamine in Ethiopia. Since 2004 artemether-lumefantrine has served to treat uncomplicated P. falciparum malaria. However, increasing reports on delayed parasite clearance to artemisinin opens up a new challenge in anti-malarial therapy. With the complete withdrawal of CQ for the treatment of Plasmodium falciparum malaria, this study assessed the evolution of CQ resistance by investigating the prevalence of mutant alleles in the pfmdr1 and pfcrt genes in P. falciparum and pvmdr1 gene in Plasmodium vivax in Southern and Eastern Ethiopia. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 2 | 2% |
Brazil | 1 | <1% |
Unknown | 118 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 24 | 20% |
Researcher | 24 | 20% |
Student > Master | 22 | 18% |
Student > Bachelor | 9 | 7% |
Other | 5 | 4% |
Other | 17 | 14% |
Unknown | 20 | 17% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 28 | 23% |
Medicine and Dentistry | 22 | 18% |
Agricultural and Biological Sciences | 20 | 17% |
Immunology and Microbiology | 7 | 6% |
Nursing and Health Professions | 5 | 4% |
Other | 13 | 11% |
Unknown | 26 | 21% |