Title |
Requirement for CDK4 kinase function in breast cancer
|
---|---|
Published in |
Cancer Cell, January 2006
|
DOI | 10.1016/j.ccr.2005.12.012 |
Pubmed ID | |
Authors |
Qunyan Yu, Ewa Sicinska, Yan Geng, Marie Ahnström, Agnieszka Zagozdzon, Yinxin Kong, Humphrey Gardner, Hiroaki Kiyokawa, Lyndsay N. Harris, Olle Stål, Piotr Sicinski |
Abstract |
Cyclin D1 is overexpressed in the majority of human breast cancers. We previously found that mice lacking cyclin D1 are resistant to mammary carcinomas triggered by the ErbB-2 oncogene. In this study, we investigated which function of cyclin D1 is required for ErbB-2-driven mammary oncogenesis. We report that the ability of cyclin D1 to activate cyclin-dependent kinase CDK4 underlies the critical role for cyclin D1 in breast cancer formation. We also found that the continued presence of CDK4-associated kinase activity is required to maintain breast tumorigenesis. We analyzed primary human breast cancers and found high cyclin D1 levels in a subset (approximately 25%) of ErbB-2-overexpressing tumors. We propose that this subset of breast cancer patients might benefit from inhibiting CDK4 kinase. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 5 | 2% |
China | 2 | <1% |
Portugal | 1 | <1% |
United Kingdom | 1 | <1% |
Japan | 1 | <1% |
Spain | 1 | <1% |
Unknown | 191 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 36 | 18% |
Student > Master | 29 | 14% |
Researcher | 25 | 12% |
Student > Bachelor | 20 | 10% |
Student > Doctoral Student | 8 | 4% |
Other | 32 | 16% |
Unknown | 52 | 26% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 46 | 23% |
Medicine and Dentistry | 39 | 19% |
Biochemistry, Genetics and Molecular Biology | 38 | 19% |
Chemistry | 7 | 3% |
Neuroscience | 4 | 2% |
Other | 10 | 5% |
Unknown | 58 | 29% |