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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Alpha-Tomatine Attenuation of In Vivo Growth of Subcutaneous and Orthotopic Xenograft Tumors of Human Prostate Carcinoma PC-3 Cells Is Accompanied by Inactivation of Nuclear Factor-Kappa B Signaling
|
|---|---|
| Published in |
PLOS ONE, February 2013
|
| DOI | 10.1371/journal.pone.0057708 |
| Pubmed ID | |
| Authors |
Sui-Ting Lee, Pooi-Fong Wong, Hui He, John David Hooper, Mohd Rais Mustafa |
| Abstract |
Nuclear factor-kappa B (NF-κB) plays a role in prostate cancer and agents that suppress its activation may inhibit development or progression of this malignancy. Alpha (α)-tomatine is the major saponin present in tomato (Lycopersicon esculentum) and we have previously reported that it suppresses tumor necrosis factor-alpha (TNF-α)-induced nuclear translocation of nuclear factor-kappa B (NF-κB) in androgen-independent prostate cancer PC-3 cells and also potently induces apoptosis of these cells. However, the precise mechanism by which α-tomatine suppresses NF-κB nuclear translocation is yet to be elucidated and the anti-tumor activity of this agent in vivo has not been examined. |
X Demographics
The data shown below were collected from the profiles of 11 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Switzerland | 1 | 9% |
| Spain | 1 | 9% |
| Germany | 1 | 9% |
| Cuba | 1 | 9% |
| France | 1 | 9% |
| Unknown | 6 | 55% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 10 | 91% |
| Scientists | 1 | 9% |
Mendeley readers
The data shown below were compiled from readership statistics for 44 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 2% |
| Poland | 1 | 2% |
| Italy | 1 | 2% |
| Germany | 1 | 2% |
| Unknown | 40 | 91% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 8 | 18% |
| Student > Master | 6 | 14% |
| Student > Bachelor | 5 | 11% |
| Researcher | 4 | 9% |
| Student > Doctoral Student | 3 | 7% |
| Other | 9 | 20% |
| Unknown | 9 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 13 | 30% |
| Medicine and Dentistry | 5 | 11% |
| Chemistry | 4 | 9% |
| Biochemistry, Genetics and Molecular Biology | 3 | 7% |
| Nursing and Health Professions | 2 | 5% |
| Other | 7 | 16% |
| Unknown | 10 | 23% |
Attention Score in Context
This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 May 2022.
All research outputs
#4,234,303
of 24,885,505 outputs
Outputs from PLOS ONE
#52,039
of 215,531 outputs
Outputs of similar age
#33,266
of 197,863 outputs
Outputs of similar age from PLOS ONE
#1,147
of 5,392 outputs
Altmetric has tracked 24,885,505 research outputs across all sources so far. Compared to these this one has done well and is in the 82nd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 215,531 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.7. This one has done well, scoring higher than 75% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 197,863 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 83% of its contemporaries.
We're also able to compare this research output to 5,392 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 78% of its contemporaries.