Title |
Impairment of autophagy in the central nervous system during lipopolysaccharide-induced inflammatory stress in mice
|
---|---|
Published in |
Molecular Brain, August 2014
|
DOI | 10.1186/s13041-014-0056-z |
Pubmed ID | |
Authors |
Arnaud Francois, Faraj Terro, Nathalie Quellard, Beatrice Fernandez, Damien Chassaing, Thierry Janet, Agnes Rioux Bilan, Marc Paccalin, Guylene Page |
Abstract |
Current evidence suggests a central role for autophagy in many neurodegenerative diseases including Alzheimer's disease, Huntington's disease, Parkinson's disease and amyotrophic lateral sclerosis. Furthermore, it is well admitted that inflammation contributes to the progression of these diseases. Interestingly, crosstalks between autophagy and inflammation have been reported in vitro and at the peripheral level such as in Crohn's disease. However, the impact of systemic inflammation on autophagic components in the brain remains to be documented. Therefore, this study monitored autophagy markers after acute and chronic lipopolysaccharide (LPS)-induced inflammatory stress in mice. |
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