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Detection of enterotoxigenic Bacteroides fragilis in patients with ulcerative colitis

Overview of attention for article published in Gut Pathogens, September 2017
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1 tweeter
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1 peer review site

Citations

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10 Dimensions

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24 Mendeley
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Title
Detection of enterotoxigenic Bacteroides fragilis in patients with ulcerative colitis
Published in
Gut Pathogens, September 2017
DOI 10.1186/s13099-017-0202-0
Pubmed ID
Authors

Samin Zamani, Sonia Hesam Shariati, Mohammad Reza Zali, Hamid Asadzadeh Aghdaei, Akram Sarabi Asiabar, Saied Bokaie, Bizhan Nomanpour, Leonardo Antonio Sechi, Mohammad Mehdi Feizabadi

Abstract

Ulcerative colitis (UC) as a type of inflammatory bowel disease (IBD), presumed to occur as a consequence of increased immune responses to intestinal microbiota in genetically susceptible individuals. Enterotoxigenic Bacteroides fragilis (ETBF) strains are important intestinal bacteria that can be involved in IBD. The aim of this study was to design a quantitative assay for detection of B. fragilis and ETBF and also to find their association with UC. Ninety-five biopsies were collected from patients with UC (n = 35) and with no IBD (nIBD, n = 60). All the specimens were cultured in Bacteroides bile esculin agar medium. Specific primers and probes were designed for quantitative real-time PCR (QRT-PCR) based on 16S rRNA and bft genes sequences of ETBF. The bft genes were detected in 51.4% of UC samples and 1.6% of nIBD samples, respectively. In UC patients, 37.1% of samples with diarrhea and 11.4% of samples without diarrhea, harbored the bft gene. Mean value of the number of ETBF with bft gene in UC and nIBD samples were 4.46 ן 10(2) and 1.96, respectively. Likewise these result for 16S rRNA gene in UC and nIBD samples were 2.0 × 10(3) and 8.4 × 10(3), respectively. There was no significant association between presence and numbers of 16S rRNA gene of B. fragilis and UC. ETBF was detected more in UC specimens and biopsies of UC patients with diarrhea than in the control group. These data demonstrated that ETBF is associated with development of UC and as a causative agent for the development of diarrhea in these patients.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 24 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 24 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 3 13%
Student > Bachelor 3 13%
Student > Ph. D. Student 3 13%
Other 2 8%
Lecturer 2 8%
Other 4 17%
Unknown 7 29%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 5 21%
Immunology and Microbiology 3 13%
Medicine and Dentistry 2 8%
Agricultural and Biological Sciences 2 8%
Veterinary Science and Veterinary Medicine 1 4%
Other 2 8%
Unknown 9 38%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 September 2017.
All research outputs
#7,083,244
of 11,843,218 outputs
Outputs from Gut Pathogens
#132
of 269 outputs
Outputs of similar age
#140,269
of 268,015 outputs
Outputs of similar age from Gut Pathogens
#5
of 7 outputs
Altmetric has tracked 11,843,218 research outputs across all sources so far. This one is in the 37th percentile – i.e., 37% of other outputs scored the same or lower than it.
So far Altmetric has tracked 269 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.5. This one is in the 43rd percentile – i.e., 43% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 268,015 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 43rd percentile – i.e., 43% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 7 others from the same source and published within six weeks on either side of this one. This one has scored higher than 2 of them.