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Genomic surveillance elucidates Ebola virus origin and transmission during the 2014 outbreak

Overview of attention for article published in Science, August 2014
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (99th percentile)

Citations

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695 Dimensions

Readers on

mendeley
1205 Mendeley
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4 CiteULike
Title
Genomic surveillance elucidates Ebola virus origin and transmission during the 2014 outbreak
Published in
Science, August 2014
DOI 10.1126/science.1259657
Pubmed ID
Authors

S. K. Gire, A. Goba, K. G. Andersen, R. S. G. Sealfon, D. J. Park, L. Kanneh, S. Jalloh, M. Momoh, M. Fullah, G. Dudas, S. Wohl, L. M. Moses, N. L. Yozwiak, S. Winnicki, C. B. Matranga, C. M. Malboeuf, J. Qu, A. D. Gladden, S. F. Schaffner, X. Yang, P.-P. Jiang, M. Nekoui, A. Colubri, M. R. Coomber, M. Fonnie, A. Moigboi, M. Gbakie, F. K. Kamara, V. Tucker, E. Konuwa, S. Saffa, J. Sellu, A. A. Jalloh, A. Kovoma, J. Koninga, I. Mustapha, K. Kargbo, M. Foday, M. Yillah, F. Kanneh, W. Robert, J. L. B. Massally, S. B. Chapman, J. Bochicchio, C. Murphy, C. Nusbaum, S. Young, B. W. Birren, D. S. Grant, J. S. Scheiffelin, E. S. Lander, C. Happi, S. M. Gevao, A. Gnirke, A. Rambaut, R. F. Garry, S. H. Khan, P. C. Sabeti

Abstract

In its largest outbreak, Ebola virus disease is spreading through Guinea, Liberia, Sierra Leone, and Nigeria. We sequenced 99 Ebola virus genomes from 78 patients in Sierra Leone to ~2000× coverage. We observed a rapid accumulation of interhost and intrahost genetic variation, allowing us to characterize patterns of viral transmission over the initial weeks of the epidemic. This West African variant likely diverged from central African lineages around 2004, crossed from Guinea to Sierra Leone in May 2014, and has exhibited sustained human-to-human transmission subsequently, with no evidence of additional zoonotic sources. Because many of the mutations alter protein sequences and other biologically meaningful targets, they should be monitored for impact on diagnostics, vaccines, and therapies critical to outbreak response.

Twitter Demographics

The data shown below were collected from the profiles of 1,560 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 1,205 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 38 3%
United Kingdom 11 <1%
Germany 8 <1%
Canada 6 <1%
France 6 <1%
Brazil 4 <1%
Switzerland 4 <1%
China 4 <1%
Japan 3 <1%
Other 27 2%
Unknown 1094 91%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 260 22%
Researcher 235 20%
Student > Bachelor 217 18%
Student > Master 161 13%
Other 62 5%
Other 270 22%
Readers by discipline Count As %
Agricultural and Biological Sciences 548 45%
Medicine and Dentistry 151 13%
Biochemistry, Genetics and Molecular Biology 141 12%
Unspecified 84 7%
Immunology and Microbiology 61 5%
Other 220 18%

Attention Score in Context

This research output has an Altmetric Attention Score of 2273. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 July 2019.
All research outputs
#573
of 13,536,671 outputs
Outputs from Science
#51
of 62,449 outputs
Outputs of similar age
#10
of 199,596 outputs
Outputs of similar age from Science
#1
of 919 outputs
Altmetric has tracked 13,536,671 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 62,449 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 44.6. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 199,596 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 919 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.