Chapter title |
The mouse digit tip: from wound healing to regeneration.
|
---|---|
Chapter number | 24 |
Book title |
Wound Regeneration and Repair
|
Published in |
Methods in molecular biology, January 2013
|
DOI | 10.1007/978-1-62703-505-7_24 |
Pubmed ID | |
Book ISBNs |
978-1-62703-504-0, 978-1-62703-505-7
|
Authors |
Simkin J, Han M, Yu L, Yan M, Muneoka K, Jennifer Simkin, Manjong Han, Ling Yu, Mingquan Yan, Ken Muneoka |
Abstract |
A challenge to the study of regeneration is determining at what point the processes of wound healing and regeneration diverge. The mouse displays level-specific regeneration responses. An amputation through the distal third of the terminal phalanx will prompt a regeneration response and result in a new digit tip that mimics the morphology of the lost digit tip. Conversely, an amputation through the distal third of the intermediate phalanx initiates a wound healing and scarring response. The mouse, therefore, provides a model for studying the transition between wound healing and regeneration in the same animal. This chapter details the methods used in the study of mammalian digit regeneration, including a method to introduce exogenous protein into the mouse digit amputation model via microcarrier beads and methods for analysis of bone regeneration. |
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