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TRPV6 calcium channel translocates to the plasma membrane via Orai1-mediated mechanism and controls cancer cell survival

Overview of attention for article published in Proceedings of the National Academy of Sciences of the United States of America, August 2014
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (85th percentile)
  • Average Attention Score compared to outputs of the same age and source

Mentioned by

news
1 news outlet

Citations

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42 Dimensions

Readers on

mendeley
54 Mendeley
Title
TRPV6 calcium channel translocates to the plasma membrane via Orai1-mediated mechanism and controls cancer cell survival
Published in
Proceedings of the National Academy of Sciences of the United States of America, August 2014
DOI 10.1073/pnas.1413409111
Pubmed ID
Authors

Maylis Raphaël, V’yacheslav Lehen’kyi, Matthieu Vandenberghe, Benjamin Beck, Sergiy Khalimonchyk, Fabien Vanden Abeele, Leonardo Farsetti, Emmanuelle Germain, Alexandre Bokhobza, Adriana Mihalache, Pierre Gosset, Christoph Romanin, Philippe Clézardin, Roman Skryma, Natalia Prevarskaya

Abstract

Transient receptor potential vanilloid subfamily member 6 (TRPV6) is a highly selective calcium channel that has been considered as a part of store-operated calcium entry (SOCE). Despite its first discovery in the early 2000s, the role of this channel in prostate cancer (PCa) remained, until now, obscure. Here we show that TRPV6 mediates calcium entry, which is highly increased in PCa due to the remodeling mechanism involving the translocation of the TRPV6 channel to the plasma membrane via the Orai1/TRPC1-mediated Ca(2+)/Annexin I/S100A11 pathway, partially contributing to SOCE. The TRPV6 calcium channel is expressed de novo by the PCa cell to increase its survival by enhancing proliferation and conferring apoptosis resistance. Xenografts in nude mice and bone metastasis models confirmed the remarkable aggressiveness of TRPV6-overexpressing tumors. Immunohistochemical analysis of these demonstrated the increased expression of clinical markers such as Ki-67, prostate specific antigen, synaptophysin, CD31, and CD56, which are strongly associated with a poor prognosis. Thus, the TRPV6 channel acquires its oncogenic potential in PCa due to the remodeling mechanism via the Orai1-mediated Ca(2+)/Annexin I/S100A11 pathway.

Mendeley readers

The data shown below were compiled from readership statistics for 54 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Italy 1 2%
United States 1 2%
Canada 1 2%
Unknown 51 94%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 11 20%
Researcher 9 17%
Student > Bachelor 7 13%
Student > Master 6 11%
Professor > Associate Professor 5 9%
Other 16 30%
Readers by discipline Count As %
Agricultural and Biological Sciences 26 48%
Biochemistry, Genetics and Molecular Biology 10 19%
Medicine and Dentistry 8 15%
Unspecified 3 6%
Chemistry 3 6%
Other 4 7%

Attention Score in Context

This research output has an Altmetric Attention Score of 8. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 August 2014.
All research outputs
#1,721,822
of 12,365,234 outputs
Outputs from Proceedings of the National Academy of Sciences of the United States of America
#25,375
of 77,344 outputs
Outputs of similar age
#30,623
of 207,740 outputs
Outputs of similar age from Proceedings of the National Academy of Sciences of the United States of America
#579
of 1,075 outputs
Altmetric has tracked 12,365,234 research outputs across all sources so far. Compared to these this one has done well and is in the 85th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 77,344 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 22.0. This one has gotten more attention than average, scoring higher than 66% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 207,740 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 85% of its contemporaries.
We're also able to compare this research output to 1,075 others from the same source and published within six weeks on either side of this one. This one is in the 45th percentile – i.e., 45% of its contemporaries scored the same or lower than it.