Title |
Use of atypical antipsychotics in the elderly: a clinical review
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Published in |
Clinical Interventions in Aging, August 2014
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DOI | 10.2147/cia.s63942 |
Pubmed ID | |
Authors |
Pietro Gareri, Cristina Segura-García, Valeria Graziella Laura Manfredi, Antonella Bruni, Paola Ciambrone, Gregorio Cerminara, Giovambattista De Sarro, Pasquale De Fazio |
Abstract |
The use of atypical antipsychotic drugs in the elderly has become wider and wider in recent years; in fact, these agents have novel receptor binding profiles, good efficacy with regard to negative symptoms, and reduced extrapyramidal symptoms. However, in recent years, the use of both conventional and atypical antipsychotics has been widely debated for concerns about their safety in elderly patients affected with dementia and the possible risks for stroke and sudden death. A MEDLINE search was made using the words elderly, atypical antipsychotics, use, schizophrenia, psychosis, mood disorders, dementia, behavioral disorders, and adverse events. Some personal studies were also considered. This paper reports the receptor binding profiles and the main mechanism of action of these drugs, together with their main use in psychiatry and the possible adverse events in elderly people. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Spain | 1 | 9% |
Belgium | 1 | 9% |
Turkey | 1 | 9% |
United States | 1 | 9% |
United Kingdom | 1 | 9% |
Unknown | 6 | 55% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 9 | 82% |
Practitioners (doctors, other healthcare professionals) | 2 | 18% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Japan | 1 | <1% |
Spain | 1 | <1% |
Germany | 1 | <1% |
Taiwan | 1 | <1% |
Unknown | 286 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 37 | 13% |
Researcher | 31 | 11% |
Student > Master | 31 | 11% |
Other | 27 | 9% |
Student > Ph. D. Student | 23 | 8% |
Other | 66 | 23% |
Unknown | 75 | 26% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 107 | 37% |
Pharmacology, Toxicology and Pharmaceutical Science | 24 | 8% |
Psychology | 18 | 6% |
Agricultural and Biological Sciences | 11 | 4% |
Neuroscience | 10 | 3% |
Other | 29 | 10% |
Unknown | 91 | 31% |